Abstract
Tooth vitality depends on pulp vitality. Conservative pulp therapy aims at preserving the coronal and radicular pulp tissues under various conditions. In order to do so, the exposed pulp tissue must be protected to sustain its vitality. The reparative process of these exposed pulp tissues consist of the replacement of the primary odontoblasts that were lost as a result of the extensive damage, with the newly differentiated odontoblast-like cells. Such process follows the procedure of proliferation, migration, and differentiation of progenitor cells.
We reported isolation and characterization of postnatal stem cells from human dental tissues; dental pulp stem cells, periodontal ligament stem cells, dental follicle stem cells and alveolar bone marrow stem cells. Also we studied about the appropriate scaffolds and conditions for those stem cells among various materials, with which each stem cell could maximize their own function.
Calcium hydroxide as one of scaffold, currently known as the gold standard of conservative pulp therapy amongst the clinicians, was investigated, and is acknowledged for stimulating the recruitment, proliferation, and mineralization steps of the postnatal dental stem cells. In addition, the animal experiment using an artificially damaged teeth, demonstrated more dentin-like tissue formation upon application of autologous dental pulp stem cells (DPSCs) combined with calcium hydroxide compared to the calcium hydroxide only. This finding is indeed worthwhile for the future availability of the DPSCs, which have been recently spotlighted as the stem cell reservoir in the regeneration of the dentin upon tooth injury and for the role of calcium hydroxide as one of scaffold in conservative pulp therapy.
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Choung, PH., Ji, YM., Choung, HW. (2012). Dental Stem Cells: Regeneration of Dentin Upon Tooth Injury. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 5. Stem Cells and Cancer Stem Cells, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2900-1_15
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DOI: https://doi.org/10.1007/978-94-007-2900-1_15
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