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Allogenic Mesenchymal Stem Cells in Experimental Ischaemic Stroke: Translation to the Clinic?

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Stem Cells and Cancer Stem Cells, Volume 5

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 5))

Abstract

Currently, only intravenous thrombolysis has been shown to be effective after ischaemic stroke. Therefore, new therapies need to be found that protect and repair the neurovascular unit after ischaemic brain damage. Cell therapy provides a good alternative for stroke treatment due to enhanced neurological recovery. Several studies have suggested that mesenchymal stem cells are appropriate for clinical use, demonstrating safety, feasibility and efficacy. However, more information about their mechanisms of action and response is needed, as well as other important data such as the appropriate cell type, timing of administration, cell delivery route and optimal dose in animal models for translational applications. This review describes recent progress in cell-based therapy, focusing on mesenchymal stem cells (bone marrow and adipose tissue) in experimental animal models and clinical trials, for the treatment of stroke.

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Authors and Affiliations

  1. Neuroscience and Cerebrovascular Research Laboratory, La Paz University Hospital, Neurosciences Area of IdiPAZ (Health Research Institute), Universidad Autónoma de Madrid, Paseo de la Castellana 261, 28046, Madrid, Spain

    María Gutiérrez-Fernández & Berta Rodríguez-Frutos

  2. Department of Neurology and Stroke Centre, La Paz University Hospital, Neurosciences Area of IdiPAZ (Health Research Institute) Universidad Autónoma de Madrid, Paseo de la Castellana 261, 28046, Madrid, Spain

    Blanca Fuentes

  3. Department of Neurology and Stroke Centre, Neuroscience and Cerebrovascular Research Laboratory, La Paz University Hospital, Neurosciences Area of IdiPAZ (Health Research Institute) Universidad Autónoma de Madrid, Paseo de la Castellana 261, 28046, Madrid, Spain

    Exuperio Díez-Tejedor

Authors
  1. María Gutiérrez-Fernández
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  2. Berta Rodríguez-Frutos
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  3. Blanca Fuentes
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  4. Exuperio Díez-Tejedor
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Correspondence to Exuperio Díez-Tejedor .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Gutiérrez-Fernández, M., Rodríguez-Frutos, B., Fuentes, B., Díez-Tejedor, E. (2012). Allogenic Mesenchymal Stem Cells in Experimental Ischaemic Stroke: Translation to the Clinic?. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 5. Stem Cells and Cancer Stem Cells, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2900-1_12

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