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Calcium Signaling in Mast Cells: Focusing on L-Type Calcium Channels

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Calcium Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 740))

Abstract

Mast cells play central roles in adaptive and innate immunity. IgE-dependent stimulation of the high-affinity IgE receptor (FcεRI) results in rapid secretion of various proinflammatory chemical mediators and cytokines. All of the outputs depend to certain degrees on an increase in the intracellular Ca2+ concentration, and influx of Ca2+ from the extracellular space is often required for their full activation. There is strong evidence that FcεRI stimulation induces two different modes of Ca2+ influx, store-operated Ca2+ entry (SOCE) and non-SOCE, which are activated in response to endoplasmic reticulum Ca2+ store depletion and independently of Ca2+ store depletion, respectively, in mast cells. Although Ca2+ release-activated Ca2+ channels are the major route of SOCE, recent evidence indicates that they are not the only Ca2+ channels activated by Ca2+ store depletion. The recent data suggest that L-type Ca2+ channels, which were thought to be a characteristic feature of excitable cells, exist in mast cells to mediate non-SOCE, which is critical for protecting mast cells against activation-induced mitochondrial cell death. In this chapter, we provide an overview of recent advances in our understanding of Ca2+ signaling in mast cells with a special attention to the emerging role for the L-type Ca2+ channels as a regulator of mast cell survival.

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Acknowledgments

The authors thank Drs. T. Yoshimaru, S. Nunomura, K. Mizuno, K. Togo, K. Hayama and T. Ochiai for their collaborations and/or technical assistance. This work was partially supported by a Grant-in-Aid for the High-Tech Research Center Project (2003–2007) for Private Universities and a matching fund subsidy for Private Universities (2007–2009) from the Ministry of Education, Culture, Sports, Science and Technology, Japan and Grants-in-Aid from Nihon University

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  1. Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, 30-1 Oyaguchikami-cho Itabashi-ku, Tokyo, 173-8610, Japan

    Yoshihiro Suzuki, Toshio Inoue & Chisei Ra

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  1. Yoshihiro Suzuki
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  2. Toshio Inoue
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Correspondence to Yoshihiro Suzuki .

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    Md. Shahidul Islam

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Suzuki, Y., Inoue, T., Ra, C. (2012). Calcium Signaling in Mast Cells: Focusing on L-Type Calcium Channels. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 740. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2888-2_44

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