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Cytoplasmic Calcium Buffering

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Calcium Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 740))

Abstract

Calcium buffering is one of the mechanisms to control calcium (Ca2+) persistence in the cytosol and hence, Ca2+ dependence of many intracellular processes. Compared with Ca2+ sequestration into intracellular Ca2+ stores, Ca2+ buffering is a rapid process occurring in sub-second scale.

Ca2+ buffers can be mobile or fixed depending of their molecular weight, but other parameters as their concentration, affinity for Ca2+ or Ca2+ binding and releasing kinetics are important to know their role in Ca2+ signaling.

This process determines Ca2+ diffusion and spatiotemporal Ca2+ signaling in the cell and is one of the basis of the versatility and complexity of Ca2+ as intracellular messenger.

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  1. Department of Toxicology and Pharmacology, Faculty of Veterinary Medicine, Complutense University of Madrid, Avda. Puerta de Hierro, s/n., 28040, Madrid, Spain

    Juan A. Gilabert

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Correspondence to Juan A. Gilabert .

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  1. , Department of Clinical Sciences and Educ, Karolinska Institutet, Tulegatan 26, Stockholm, SE-118 83, Sweden

    Md. Shahidul Islam

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Gilabert, J.A. (2012). Cytoplasmic Calcium Buffering. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 740. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2888-2_20

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