Abstract
Essential properties of biosensors for continuous monitoring in blood and tissue are selectivity, sensitivity and biocompatibility. A variety of membranes have been explored to achieve these properties. A good understanding of the diffusion properties of analytes and interferent species through these membranes is important for improvement of design and the understanding of response change in complex biological matrix. A simple analytical expression for the accurate determination of diffusion coefficient of analytes through biofilms and cylindrical granules is described and its application for biosensing presented. A general, needle-based, amperometric platform for the continuous monitoring of oxygen, glucose and lactate is also described, most notably a recess tip format, and some considerations on biosensor design and application are discussed.
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The authors thank EPSRC for generous funding through Project EP/H009744/1 (ESPRIT).
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Spehar-Délèze, AM., Anastasova, S., Rong, Z., Bickham, D., Chang, H., Vadgama, P. (2012). General Platform for In Vivo Sensors for Oxygen, Glucose and Lactate Monitoring. In: Nikolelis, D. (eds) Portable Chemical Sensors. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2872-1_16
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DOI: https://doi.org/10.1007/978-94-007-2872-1_16
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