Intraspinal Oncocytic Adrenocortical Adenoma: Diagnosis
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Oncocytic adrenocortical adenomas are rare non-functioning variants of adrenal cortical adenomas. To date at least seven intraspinal tumors have been observed. The tumors are positive for Melan A, synaptophysin, focally cytokeratins 8 and 18, while S-100, chromogranin and HMB45 are negative. Typically there is abundant mitochondria in electron microscopy. Differential diagnosis includes tumors with oncocytic changes as paraganglioma, meningioma, alveolar soft part sarcoma, granular cell tumor and carcinoma. An overview of these rare, but probably underdiagnosed intraspinal tumors is given.
KeywordsEpithelial tumor Adenoma Oncocytoma
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