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Plasma for Bio-Decontamination, Medicine and Food Security pp 403–416Cite as

Generation of Focused Shock Waves in Water for Biomedical Applications

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Abstract

The physical characteristics of focused two-successive (tandem) shock waves (FTSW) in water and their biological effects are presented. FTSW were ­generated by underwater multichannel electrical discharges in a highly conductive saline solution using two porous ceramic-coated cylindrical electrodes of different diameter and surface area. The primary cylindrical pressure wave generated at each composite electrode was focused by a metallic parabolic reflector to a common focal point to form two strong shock waves with a variable time delay between the waves. The pressure field and interaction between the first and the second shock waves at the focus were investigated using schlieren photography and polyvinylidene fluoride (PVDF) shock gauge sensors. The largest interaction was obtained for a time delay of 8–15 μs between the waves, producing an amplitude of the negative pressure phase of the second shock wave down to −80 MPa and a large number of cavitations at the focus. The biological effects of FTSW were demonstrated in vitro on damage to B16 melanoma cells, in vivo on targeted lesions in the thigh muscles of rabbits and on the growth delay of sarcoma tumors in Lewis rats treated in vivo by FTSW, compared to untreated controls.

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Acknowledgements

This work was supported by the Czech Science Foundation (project No. 202/09/1151) and the Ministry of Education, Youth and Sports of the Czech Republic (MSM 0021620808). The authors would like to thank Dr. V. Horak from the Institute of Animal Physiology and Genetics AS CR for providing R5-28 malignant cells for the experiments with the Lewis rats, Dr. V. Herynek and Dr. M. Dezortova from the Institute for Clinical and Experimental Medicine, Prague, Czech Republic for the MRI analysis of the lesions in the rabbits’ thighs and Dr. J. Kralova from the Institute of Molecular Genetics AS CR for optical micrographs of the melanoma B16 cells.

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Authors and Affiliations

  1. Institute of Plasma Physics, Academy of Sciences of the Czech Republic, Za Slovankou 3, 18200, Prague, Czech Republic

    Petr Lukeš, Pavel Šunka, Petr Hoffer & Vitaliy Stelmashuk

  2. First Faculty of Medicine, Charles University, Prague, Czech Republic

    Jiří Beneš, Pavla Poučková, Marie Zadinová & Jan Zeman

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  1. Petr Lukeš
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  2. Pavel Šunka
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  3. Petr Hoffer
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  4. Vitaliy Stelmashuk
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  5. Jiří Beneš
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  6. Pavla Poučková
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  7. Marie Zadinová
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  8. Jan Zeman
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Correspondence to Petr Lukeš .

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Editors and Affiliations

  1. , Faculty of Math., Phys. and Informatics, Comenius University, Mlynska Dolina, Bratislava, 84248, Slovakia

    Zdenko Machala

  2. , Faculty of Math., Phys. and Informatics, Comenius University, Mlynska Dolina, Bratislava, 84248, Slovakia

    Karol Hensel

  3. SRC RF Triniti, Pushkovykh 12, Troitsk, 142190, Russia

    Yuri Akishev

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© 2012 Springer Science+Business Media B.V.

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Lukeš, P. et al. (2012). Generation of Focused Shock Waves in Water for Biomedical Applications. In: Machala, Z., Hensel, K., Akishev, Y. (eds) Plasma for Bio-Decontamination, Medicine and Food Security. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2852-3_31

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