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Integrative Systems Biology II—Molecular Biology: Phase 2 Lead Discovery and In Silico Screening

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Systems Biology in Biotech & Pharma

Part of the book series: SpringerBriefs in Pharmaceutical Science & Drug Development ((BRIEFSPSDD,volume 2))

Abstract

Many different OMICs/HTS techniques now allow huge amounts of molecular signatures to be collected and then analysed further by system tools. Among them, ChIP-on-chip is used to investigate interactions between proteins and DNA in vivo. Chemogenomics, morphogenics and synthetic biology are only in the early stages of development, but may contribute to target identification. A key SB tool, the reconstruction of biological networks, represents an emerging field, undergoing explosive expansion, and will likely enable efficient mapping of gene onto function.

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Authors and Affiliations

  1. Chemical and Biomolecular Engineering, Vanderbilt University, VU Station B 351604, Nashville, TN, 37235, USA

    Aleš Prokop

  2. NanoDelivery International, s.r.o., 1327/113 Nádražní, 69141, Břeclav-Poštorná, Czech Republic

    Aleš Prokop

  3. Genomic Health Inc, 101 Galveston Dr, Redwood City, CA, 94063, USA

    Seth Michelson

Authors
  1. Aleš Prokop
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  2. Seth Michelson
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Correspondence to Aleš Prokop .

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Prokop, A., Michelson, S. (2012). Integrative Systems Biology II—Molecular Biology: Phase 2 Lead Discovery and In Silico Screening. In: Systems Biology in Biotech & Pharma. SpringerBriefs in Pharmaceutical Science & Drug Development, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2849-3_4

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  • DOI: https://doi.org/10.1007/978-94-007-2849-3_4

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-2848-6

  • Online ISBN: 978-94-007-2849-3

  • eBook Packages: MedicineMedicine (R0)

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