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Integrative Systems Biology I—Biochemistry: Phase I Lead Discovery and Molecular Interactions

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Systems Biology in Biotech & Pharma

Part of the book series: SpringerBriefs in Pharmaceutical Science & Drug Development ((BRIEFSPSDD,volume 2))

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Abstract

This chapter represents a mix of reductionist and holistic tools. Molecular screens and Biomimetics represent advanced reductionist approaches—the former are well established in the industry, although still developing. Similarly, the collateral efficacy/permissive antagonism concept may add to this effort, possibly generating new targets. Solving different co-drugging modalities represents a typical SB approach. Likewise, text mining does add to the holistic (global) effort. Tools to analyze biochemical networks and the phenomenon of emergence may lead to the establishment of ‘new biology’ or computational systems biology (CSB). Reactome analysis and bioinformatics tools only reinforce this effort. The level of development of the above quantitative tools is not uniform: some are advanced and mature (e.g., molecular screens), some require more inputs and are undergoing rapid evolution.

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Authors and Affiliations

  1. Chemical and Biomolecular Engineering, Vanderbilt University, VU Station B 351604, Nashville, TN, 37235, USA

    Aleš Prokop

  2. NanoDelivery International, s.r.o., 1327/113 Nádražní, 69141, Břeclav-Poštorná, Czech Republic

    Aleš Prokop

  3. Genomic Health Inc, 101 Galveston Dr, Redwood City, CA, 94063, USA

    Seth Michelson

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  1. Aleš Prokop
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  2. Seth Michelson
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Correspondence to Aleš Prokop .

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Prokop, A., Michelson, S. (2012). Integrative Systems Biology I—Biochemistry: Phase I Lead Discovery and Molecular Interactions. In: Systems Biology in Biotech & Pharma. SpringerBriefs in Pharmaceutical Science & Drug Development, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2849-3_3

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  • DOI: https://doi.org/10.1007/978-94-007-2849-3_3

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-2848-6

  • Online ISBN: 978-94-007-2849-3

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