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Breast Cancer Stem Cell: Translating to the Clinic

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Stem Cells and Cancer Stem Cells, Volume 4

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 4))

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Abstract

Breast cancer is the most common cancer in women in both Western and Asian countries. Despite development of systemic chemotherapy, metastatic breast cancers are still incurable. Currently, evidence supports that a small subpopulation composed of cancer stem cells (CSCs) in a tumor can have self-renewing ability and tumorigenesis, and generate tumor to recapitulate a heterogeneous population of cancer cells in hierarchical fashion. Accordingly, CSC hypothesis brings a paradigm shift for breast cancer biology and treatment strategies. To elucidate how CSCs affect a person’s risk and progression of breast cancer, many clinical trials for CSC-targeted therapeutics are ongoing.

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Acknowledgements

This work was supported in part by a Grant-in-aid for the Third-Term Comprehensive 10-Year Strategy for Cancer Control, the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NiBio), and the Japan Society for the Promotion of Science (JSPS) through the “Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program),” initiated by the Council for Science and Technology Policy (CSTP).

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Authors and Affiliations

  1. Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo, Japan

    Makiko Ono & Takahiro Ochiya

  2. Breast and Medical Oncology Division, National Cancer Center Hospital, Tsukiji, Chuo-ku, Tokyo, Japan

    Yasuhiro Fujiwara

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  1. Makiko Ono
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  2. Yasuhiro Fujiwara
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  3. Takahiro Ochiya
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Correspondence to Takahiro Ochiya .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Ono, M., Fujiwara, Y., Ochiya, T. (2012). Breast Cancer Stem Cell: Translating to the Clinic. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 4. Stem Cells and Cancer Stem Cells, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2828-8_22

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