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Stem Cells and Cancer Stem Cells, Volume 4 pp 161–174Cite as

Cellularized Scaffolds: New Clothes for Cardiac Regenerative Medicine

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Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 4))

Abstract

Current practice of medical therapy and mechanical revascularization may stabilize symptoms post-myocardial infarction, but they do not address fundamental issue of significant loss of contractile units of cardiac muscle. Patients devastated by massive infarction and adverse remodeling of left ventricle (LV) require drastic remedies to avert dire consequences of congestive heart failure. Currently, mechanical circulatory supporting devices such as left ventricular assist device (LVAD) and biventricular assist device (BiVAD) are being offered as an acceptable bridging measure until heart transplant, but are plaqued by technical issues and high costs of such interventions. Tissue engineered cardiac construct is being considered as an alternative bridging measure for such patients. These constructs are often reconstituted by natural matrices or synthesis polymers to serve as scaffolding carriers for repopulating stem cells. These cellularized scaffolds serve to restrain LV dilatation from adverse remodeling and support weakened myocardial wall in post-infarcted heart. The scaffolds have been designed to biodegrade over a period of time and tuned to adapt to varying mechanical property to impart elasticity and mechanical strength that match the milieu requirements of failing heart. In this chapter, we focus on the types of scaffolds that are being considered as most appropriate for clinical adoption. Their implications in the context of cellular carrier and vascular conduits for cardiac regenerative medicine are emphasized.

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Authors and Affiliations

  1. Research and Development Unit, National Heart Centre, 9 Hospital Drive, School of Nursing, #03-02, Block C, SingHealth Research Facilities, Singapore, 169612, Singapore

    Kee Pah Lim, Ling Qian, Philip Wong & Winston Shim

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  1. Kee Pah Lim
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  2. Ling Qian
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  3. Philip Wong
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  4. Winston Shim
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Correspondence to Winston Shim .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Lim, K.P., Qian, L., Wong, P., Shim, W. (2012). Cellularized Scaffolds: New Clothes for Cardiac Regenerative Medicine. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 4. Stem Cells and Cancer Stem Cells, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2828-8_15

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