Abstract
Recent developments in SC research have driven a rush to find the best iPSC protocol, increasing studies into reprogramming efficiency and animal transplantation. However, limits to the clinical use of iPSCs remain. It is also important to continue parallel studies into ESCs, given its longer history and consequently more advanced knowledge base. Both fields of research stand to benefit from each other, and so personalized SC therapies will develop more rapidly using a combined approach.
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References
Barrilleaux B, Knoepfler PS (2011a) Inducing iPSCs to escape the dish. Cell Stem Cell 9:103–111
Barrilleaux B, Knoepfler PS (2011b) Inducing iPSCs to escape the dish. Cell Stem Cell 9:103–111
Hanna J, Wernig M, Markoulaki S, Sun CW, Meissner A, Cassady JP, Beard C, Brambrink T, Wu LC, Townes TM, Jaenisch R (2007) Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 318:1920–1923
Miyoshi N, Ishii H, Nagano H, Haraguchi N, Dewi DL, Kano Y, Ni-shikawa S, Tanemura M, Mimori K, Tanaka F, Saito T, Ni-shimura J, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Doki Y, Mori M (2011) Reprogramming of mouse and human cells to pluripotency using mature mi-croRNAs. Cell Stem Cell 8:633–638
Morizane A, Li JY, Brundin P (2008) From bench to bed: the poten-tial of stem cells for the treatment of Parkinson’s disease. Cell Tissue Res. 331:323–336
Rodriguez-Piza I, Richaud-Patin Y, Vassena R, Gonzalez F, Barrero MJ, Veiga A, Raya A, Belmonte JC (2010) Reprogramming of human fibroblasts to induced pluripotent stem cells under xeno-free conditions. Stem Cells 28:36–44
Taylor CJ, Bolton EM, Bradley JA (2011) Immunological considerations for embryonic and induced pluripotent stem cell banking. Philos Trans R Soc Lond B Biol Sci 366:2312–2322
Zhao T, Zhang ZN, Rong Z, Xu Y (2011a) Immunogenicity of in-duced pluripotent stem cells. Nature 474:212–215
Zhao T, Zhang ZN, Rong Z, Xu Y (2011b) Immunogenicity of in-duced pluripotent stem cells. Nature 474:212–215
Zhou H, Wu S, Joo JY, Zhu S, Han DW, Lin T, Trauger S, Bien G, Yao S, Zhu Y, Siuzdak G, Scholer HR, Duan L, Ding S (2009) Generation of induced pluripotent stem cells using re-combinant proteins. Cell Stem Cell 4:381–384
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Heine, V.M., Dooves, S., Holmes, D., Wagner, J. (2012). Conclusions. In: Induced Pluripotent Stem Cells in Brain Diseases. SpringerBriefs in Neuroscience. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2816-5_4
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DOI: https://doi.org/10.1007/978-94-007-2816-5_4
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