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Stem Cells and Human Diseases pp 197–216Cite as

Ischemia, Reactive Radicals, Redox Signaling and Hematopoietic Stem Cells

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Abstract

Ischemia is a medical condition generated by inadequate or no blood flow to the organs such as heart, brain, limbs and kidney, contributes to the pathophysiology of several diseases such as myocardial infarction, cerebral ischemia (stroke), peripheral vascular insufficiency and hypovolemic shock etc. As a result of ischemic insult, cascades of metabolic and ultra structural changes occur at the cellular level resulted in irreversible tissue injury and cell death. Several pharmacological interventions such as antioxidant therapy, anti-inflammatory therapy along with reperfusion strategies have been tried for several decades to protect the affected tissue from necrosis and cell death after ischemic insult. But, none of these interventions had proven to be cure for ischemia. Thus, novel therapeutic approach such as stem cell becomes very popular in the field of regenerative medicine to treat post ischemic conditions and to improve patient lifestyle as an alternate. Hematopoietic stem and progenitor cells from different sources showed promise to the ischemic therapy. Human umbilical cord blood-derived stem cells are one of the most promising cells that have shown beneficial effects in treating ischemic disorders in pre-clinical models and some clinical trials. However, several hurdles such as adequate supply of stem cells, suitable route of administration, need to be addressed to use as a regular therapeutic regiment for ischemic patients in the clinic.

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References

  1. Abbott RD, Donahue RP, Kannel WB, Wilson PW (1988) The impact of diabetes on survival following myocardial infarction in men vs women. The Framingham study. JAMA 260(23):3456–3460

    Article  PubMed  CAS  Google Scholar 

  2. Abete P, Cioppa A, Calabrese C, Pascucci I, Cacciatore F, Napoli C, Carnovale V, Ferrara N, Rengo F (1999) Ischemic threshold and myocardial stunning in the aging heart. Exp Gerontol 34(7):875–884

    Article  PubMed  CAS  Google Scholar 

  3. Adler DS, Lazarus H, Nair R, Goldberg JL, Greco NJ, Lassar T, Laughlin MJ, Das H, Pompili VJ (2011) Safety and efficacy of bone marrow-derived autologous CD133+ stem cell therapy. Front Biosci (Elite Ed) 3:506–514

    Article  Google Scholar 

  4. Ambrosio G, Flaherty JT, Duilio C, Tritto I, Santoro G, Elia PP, Condorelli M, Chiariello M (1991) Oxygen radicals generated at reflow induce peroxidation of membrane lipids in reperfused hearts. J Clin Invest 87(6):2056–2066

    Article  PubMed  CAS  Google Scholar 

  5. Ambrosio G, Zweier JL, Duilio C, Kuppusamy P, Santoro G, Elia PP, Tritto I, Cirillo P, Condorelli M, Chiariello M et al (1993) Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow. J Biol Chem 268(25):18532–18541

    PubMed  CAS  Google Scholar 

  6. Ames A 3rd, Wright RL, Kowada M, Thurston JM, Majno G (1968) Cerebral ischemia. II. The no-reflow phenomenon. Am J Pathol 52(2):437–453

    PubMed  Google Scholar 

  7. Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M, Kearne M, Magner M, Isner JM (1999) Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 85(3):221–228

    PubMed  CAS  Google Scholar 

  8. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science 275(5302):964–967

    Article  PubMed  CAS  Google Scholar 

  9. Baigent C, Keech A, Kearney PM, Blackwell L, Buck G, Pollicino C, Kirby A, Sourjina T, Peto R, Collins R, Simes R (2005) Efficacy and safety of cholesterol-lowering treatment: ­prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 366(9493):1267–1278

    Article  PubMed  CAS  Google Scholar 

  10. Bang OY, Lee JS, Lee PH, Lee G (2005) Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 57(6):874–882

    Article  PubMed  Google Scholar 

  11. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87(4):1620–1624

    Article  PubMed  CAS  Google Scholar 

  12. Bernecker OY, Huq F, Heist EK, Podesser BK, Hajjar RJ (2003) Apoptosis in heart failure and the senescent heart. Cardiovasc Toxicol 3(3):183–190

    Article  PubMed  CAS  Google Scholar 

  13. Bliss T, Guzman R, Daadi M, Steinberg GK (2007) Cell transplantation therapy for stroke. Stroke 38(2 Suppl):817–826

    Article  PubMed  Google Scholar 

  14. Bolli R, Becker L, Gross G, Mentzer R Jr, Balshaw D, Lathrop DA (2004) Myocardial protection at a crossroads: the need for translation into clinical therapy. Circ Res 95(2):125–134

    Article  PubMed  CAS  Google Scholar 

  15. Bolli R, Patel BS, Jeroudi MO, Lai EK, McCay PB (1988) Demonstration of free radical generation in “stunned” myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone. J Clin Invest 82(2):476–485

    Article  PubMed  CAS  Google Scholar 

  16. Brennan JP, Bardswell SC, Burgoyne JR, Fuller W, Schroder E, Wait R, Begum S, Kentish JC, Eaton P (2006) Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation. J Biol Chem 281(31):21827–21836

    Article  PubMed  CAS  Google Scholar 

  17. Buja LM (1998) Modulation of the myocardial response to ischemia. Lab Invest 78(11):1345–1373

    PubMed  CAS  Google Scholar 

  18. Burwell LS, Brookes PS (2008) Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia-reperfusion injury. Antioxid Redox Signal 10(3):579–599

    Article  PubMed  CAS  Google Scholar 

  19. Buzanska L, Jurga M, Stachowiak EK, Stachowiak MK, Domanska-Janik K (2006) Neural stem-like cell line derived from a nonhematopoietic population of human umbilical cord blood. Stem Cells Dev 15(3):391–406

    Article  PubMed  CAS  Google Scholar 

  20. Carden DL, Granger DN (2000) Pathophysiology of ischaemia-reperfusion injury. J Pathol 190(3):255–266

    Article  PubMed  CAS  Google Scholar 

  21. Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M, Chopp M (2001) Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32(4):1005–1011

    Article  PubMed  CAS  Google Scholar 

  22. Chiang N, Gronert K, Clish CB, O’Brien JA, Freeman MW, Serhan CN (1999) Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion. J Clin Invest 104(3):309–316

    Article  PubMed  CAS  Google Scholar 

  23. Csiszar A, Pacher P, Kaley G, Ungvari Z (2005) Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging. Curr Vasc Pharmacol 3(3):285–291

    Article  PubMed  CAS  Google Scholar 

  24. Das H, Abdulhameed N, Joseph M, Sakthivel R, Mao HQ, Pompili VJ (2009) Ex vivo nanofiber expansion and genetic modification of human cord blood-derived progenitor/stem cells enhances vasculogenesis. Cell Transplant 18(3):305–318

    Article  PubMed  Google Scholar 

  25. Das H, George JC, Joseph M, Das M, Abdulhameed N, Blitz A, Khan M, Sakthivel R, Mao HQ, Hoit BD, Kuppusamy P, Pompili VJ (2009) Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model. PLoS One 4(10):e7325

    Article  PubMed  CAS  Google Scholar 

  26. Dearden NM (1985) Ischaemic brain. Lancet 2(8449):255–259

    Article  PubMed  CAS  Google Scholar 

  27. Dhalla NS, Elmoselhi AB, Hata T, Makino N (2000) Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res 47(3):446–456

    Article  PubMed  CAS  Google Scholar 

  28. Donahoe SM, Stewart GC, McCabe CH, Mohanavelu S, Murphy SA, Cannon CP, Antman EM (2007) Diabetes and mortality following acute coronary syndromes. JAMA 298(7):765–775

    Article  PubMed  CAS  Google Scholar 

  29. Eaton P (2006) Protein thiol oxidation in health and disease: techniques for measuring ­disulfides and related modifications in complex protein mixtures. Free Radic Biol Med 40(11):1889–1899

    Article  PubMed  CAS  Google Scholar 

  30. Fang J, Alderman MH (2006) Impact of the increasing burden of diabetes on acute myocardial infarction in New York City: 1990–2000. Diabetes 55(3):768–773

    Article  PubMed  CAS  Google Scholar 

  31. Fang J, Mensah GA, Alderman MH, Croft JB (2006) Trends in acute myocardial infarction complicated by cardiogenic shock, 1979–2003, United States. Am Heart J 152(6):1035–1041

    Article  PubMed  Google Scholar 

  32. Ferdinandy P, Schulz R (2003) Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning. Br J Pharmacol 138(4):532–543

    Article  PubMed  CAS  Google Scholar 

  33. Ferdinandy P, Schulz R, Baxter GF (2007) Interaction of cardiovascular risk factors with ­myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev 59(4):418–458

    Article  PubMed  CAS  Google Scholar 

  34. Feuerstein GZ, Chavez J (2009) Translational medicine for stroke drug discovery: the pharmaceutical industry perspective. Stroke 40(3 Suppl):S121–S125

    Article  PubMed  CAS  Google Scholar 

  35. Feuerstein GZ, Zaleska MM, Krams M, Wang X, Day M, Rutkowski JL, Finklestein SP, Pangalos MN, Poole M, Stiles GL, Ruffolo RR, Walsh FL (2008) Missing steps in the STAIR case: a translational medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke. J Cereb Blood Flow Metab 28(1):217–219

    Article  PubMed  CAS  Google Scholar 

  36. Gross ER, Hsu AK, Gross GJ (2004) Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. Circ Res 94(7):960–966

    Article  PubMed  CAS  Google Scholar 

  37. Hanlon PR, Fu P, Wright GL, Steenbergen C, Arcasoy MO, Murphy E (2005) Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling. FASEB J 19(10):1323–1325

    PubMed  CAS  Google Scholar 

  38. Hausenloy DJ, Duchen MR, Yellon DM (2003) Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury. Cardiovasc Res 60(3):617–625

    Article  PubMed  CAS  Google Scholar 

  39. Hemingway H, Malik M, Marmot M (2001) Social and psychosocial influences on sudden cardiac death, ventricular arrhythmia and cardiac autonomic function. Eur Heart J 22(13):1082–1101

    Article  PubMed  CAS  Google Scholar 

  40. Hertz L (1981) Features of astrocytic function apparently involved in the response of central nervous tissue to ischemia-hypoxia. J Cereb Blood Flow Metab 1(2):143–153

    Article  PubMed  CAS  Google Scholar 

  41. Hess DT, Matsumoto A, Nudelman R, Stamler JS (2001) S-nitrosylation: spectrum and specificity. Nat Cell Biol 3(2):E46–E49

    Article  PubMed  CAS  Google Scholar 

  42. Hess ML, Manson NH (1984) Molecular oxygen: friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury. J Mol Cell Cardiol 16(11):969–985

    Article  PubMed  CAS  Google Scholar 

  43. Hickey MJ, Hurley JV, Angel MF, O’Brien BM (1992) The response of the rabbit rectus ­femoris muscle to ischemia and reperfusion. J Surg Res 53(4):369–377

    Article  PubMed  CAS  Google Scholar 

  44. Inagaki K, Chen L, Ikeno F, Lee FH, Imahashi K, Bouley DM, Rezaee M, Yock PG, Murphy E, Mochly-Rosen D (2003) Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo. Circulation 108(19):2304–2307

    Article  PubMed  CAS  Google Scholar 

  45. Jaffe JR, Nag SS, Landsman PB, Alexander CM (2006) Reassessment of cardiovascular risk in diabetes. Curr Opin Lipidol 17(6):644–652

    Article  PubMed  CAS  Google Scholar 

  46. Jelnes R, Gaardsting O, Hougaard Jensen K, Baekgaard N, Tonnesen KH, Schroeder T (1986) Fate in intermittent claudication: outcome and risk factors. Br Med J (Clin Res Ed) 293(6555):1137–1140

    Article  CAS  Google Scholar 

  47. Jennings RB, Sommers HM, Smyth GA, Flack HA, Linn H (1960) Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog. Arch Pathol 70:68–78

    PubMed  CAS  Google Scholar 

  48. Jerome SN, Akimitsu T, Gute DC, Korthuis RJ (1995) Ischemic preconditioning attenuates capillary no-reflow induced by prolonged ischemia and reperfusion. Am J Physiol 268(5 Pt 2):H2063–H2067

    PubMed  CAS  Google Scholar 

  49. Jones DP (2006) Disruption of mitochondrial redox circuitry in oxidative stress. Chem Biol Interact 163(1–2):38–53

    Article  PubMed  CAS  Google Scholar 

  50. Judge S, Jang YM, Smith A, Hagen T, Leeuwenburgh C (2005) Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging. FASEB J 19(3):419–421

    PubMed  CAS  Google Scholar 

  51. Kamihata H, Matsubara H, Nishiue T, Fujiyama S, Tsutsumi Y, Ozono R, Masaki H, Mori Y, Iba O, Tateishi E, Kosaki A, Shintani S, Murohara T, Imaizumi T, Iwasaka T (2001) Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines. Circulation 104(9):1046–1052

    Article  PubMed  CAS  Google Scholar 

  52. Kannel WB, McGee DL (1979) Diabetes and cardiovascular disease. The Framingham study. JAMA 241(19):2035–2038

    Article  PubMed  CAS  Google Scholar 

  53. Kanski J, Behring A, Pelling J, Schoneich C (2005) Proteomic identification of 3-­nitrotyrosine-containing rat cardiac proteins: effects of biological aging. Am J Physiol Heart Circ Physiol 288(1):H371–H381

    Article  PubMed  CAS  Google Scholar 

  54. Kaplan J, Dimlich RV, Biros MH, Hedges J (1987) Mechanisms of ischemic cerebral injury. Resuscitation 15(3):149–169

    Article  PubMed  CAS  Google Scholar 

  55. Kim BO, Tian H, Prasongsukarn K, Wu J, Angoulvant D, Wnendt S, Muhs A, Spitkovsky D, Li RK (2005) Cell transplantation improves ventricular function after a myocardial infarction: a preclinical study of human unrestricted somatic stem cells in a porcine model. Circulation 112(9 Suppl):I96–I104

    PubMed  Google Scholar 

  56. Klein L, Gheorghiade M (2004) Management of the patient with diabetes mellitus and myocardial infarction: clinical trials update. Am J Med 116(Suppl 5A):47S–63S

    Article  PubMed  Google Scholar 

  57. Kloner RA, Przyklenk K, Shook T, Cannon CP (1998) Protection conferred by preinfarct angina is manifest in the aged heart: evidence from the TIMI 4 trial. J Thromb Thrombolysis 6(2):89–92

    Article  PubMed  Google Scholar 

  58. Kondziolka D, Steinberg GK, Wechsler L, Meltzer CC, Elder E, Gebel J, Decesare S, Jovin T, Zafonte R, Lebowitz J, Flickinger JC, Tong D, Marks MP, Jamieson C, Luu D, Bell-Stephens T, Teraoka J (2005) Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial. J Neurosurg 103(1):38–45

    Article  PubMed  Google Scholar 

  59. Kunz A, Park L, Abe T, Gallo EF, Anrather J, Zhou P, Iadecola C (2007) Neurovascular protection by ischemic tolerance: role of nitric oxide and reactive oxygen species. J Neurosci 27(27):7083–7093

    Article  PubMed  CAS  Google Scholar 

  60. Kwiatkowski TG, Libman RB, Frankel M, Tilley BC, Morgenstern LB, Lu M, Broderick JP, Lewandowski CA, Marler JR, Levine SR, Brott T (1999) Effects of tissue plasminogen activator for acute ischemic stroke at one year. National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Study Group. N Engl J Med 340(23):1781–1787

    Article  PubMed  CAS  Google Scholar 

  61. Lee RJ, Springer ML, Blanco-Bose WE, Shaw R, Ursell PC, Blau HM (2000) VEGF gene delivery to myocardium: deleterious effects of unregulated expression. Circulation 102(8):898–901

    PubMed  CAS  Google Scholar 

  62. Lefer DJ, Granger DN (2000) Oxidative stress and cardiac disease. Am J Med 109(4):315–323

    Article  PubMed  CAS  Google Scholar 

  63. Lesnefsky EJ, Moghaddas S, Tandler B, Kerner J, Hoppel CL (2001) Mitochondrial dysfunction in cardiac disease: ischemia–reperfusion, aging, and heart failure. J Mol Cell Cardiol 33(6):1065–1089

    Article  PubMed  CAS  Google Scholar 

  64. Lewington S, Whitlock G, Clarke R, Sherliker P, Emberson J, Halsey J, Qizilbash N, Peto R, Collins R (2007) Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet 370(9602):1829–1839

    Article  PubMed  CAS  Google Scholar 

  65. Li Y, Ma T, Kniss DA, Yang ST, Lasky LC (2001) Human cord cell hematopoiesis in three-dimensional nonwoven fibrous matrices: in vitro simulation of the marrow microenvironment. J Hematother Stem Cell Res 10(3):355–368

    Article  PubMed  CAS  Google Scholar 

  66. Lim SY, Davidson SM, Hausenloy DJ, Yellon DM (2007) Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore. Cardiovasc Res 75(3):530–535

    Article  PubMed  CAS  Google Scholar 

  67. Maxwell SR, Lip GY (1997) Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options. Int J Cardiol 58(2):95–117

    Article  PubMed  CAS  Google Scholar 

  68. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A, Anversa P (2001) Bone marrow cells regenerate infarcted myocardium. Nature 410(6829):701–705

    Article  PubMed  CAS  Google Scholar 

  69. Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, Nadal-Ginard B, Bodine DM, Leri A, Anversa P (2001) Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci USA 98(18):10344–10349

    Article  PubMed  CAS  Google Scholar 

  70. Otani A, Kinder K, Ewalt K, Otero FJ, Schimmel P, Friedlander M (2002) Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis. Nat Med 8(9):1004–1010

    Article  PubMed  CAS  Google Scholar 

  71. Oudot A, Martin C, Busseuil D, Vergely C, Demaison L, Rochette L (2006) NADPH oxidases are in part responsible for increased cardiovascular superoxide production during aging. Free Radic Biol Med 40(12):2214–2222

    Article  PubMed  CAS  Google Scholar 

  72. Pacher P, Beckman JS, Liaudet L (2007) Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87(1):315–424

    Article  PubMed  CAS  Google Scholar 

  73. Panes J, Perry M, Granger DN (1999) Leukocyte-endothelial cell adhesion: avenues for therapeutic intervention. Br J Pharmacol 126(3):537–550

    Article  PubMed  CAS  Google Scholar 

  74. Parks DA, Granger DN (1986) Contributions of ischemia and reperfusion to mucosal lesion formation. Am J Physiol 250(6 Pt 1):G749–G753

    PubMed  CAS  Google Scholar 

  75. Passier R, van Laake LW, Mummery CL (2008) Stem-cell-based therapy and lessons from the heart. Nature 453(7193):322–329

    Article  PubMed  CAS  Google Scholar 

  76. Rafii S, Lyden D (2003) Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med 9(6):702–712

    Article  PubMed  CAS  Google Scholar 

  77. Rehncrona S (1985) Brain acidosis. Ann Emerg Med 14(8):770–776

    Article  PubMed  CAS  Google Scholar 

  78. Reichelt KL (1968) The chemical basis for the intolerance of the brain to anoxia. Acta Anaesthesiol Scand Suppl 29:35–46

    Article  PubMed  CAS  Google Scholar 

  79. Rozanski A, Blumenthal JA, Kaplan J (1999) Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation 99(16):2192–2217

    PubMed  CAS  Google Scholar 

  80. Saini HK, Machackova J, Dhalla NS (2004) Role of reactive oxygen species in ischemic ­preconditioning of subcellular organelles in the heart. Antioxid Redox Signal 6(2):393–404

    Article  PubMed  CAS  Google Scholar 

  81. Simoons ML, Boersma E, Maas AC, Deckers JW (1997) Management of myocardial infarction: the proper priorities. Eur Heart J 18(6):896–899

    PubMed  CAS  Google Scholar 

  82. Sivonova M, Tatarkova Z, Durackova Z, Dobrota D, Lehotsky J, Matakova T, Kaplan P (2007) Relationship between antioxidant potential and oxidative damage to lipids, proteins and DNA in aged rats. Physiol Res 56(6):757–764

    PubMed  CAS  Google Scholar 

  83. Stamm C, Westphal B, Kleine HD, Petzsch M, Kittner C, Klinge H, Schumichen C, Nienaber CA, Freund M, Steinhoff G (2003) Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 361(9351):45–46

    Article  PubMed  Google Scholar 

  84. Stanevsky A, Goldstein G, Nagler A (2009) Umbilical cord blood transplantation: pros, cons and beyond. Blood Rev 23(5):199–204

    Article  PubMed  Google Scholar 

  85. Strike PC, Steptoe A (2003) Systematic review of mental stress-induced myocardial ischaemia. Eur Heart J 24(8):690–703

    Article  PubMed  CAS  Google Scholar 

  86. Taguchi A, Soma T, Tanaka H, Kanda T, Nishimura H, Yoshikawa H, Tsukamoto Y, Iso H, Fujimori Y, Stern DM, Naritomi H, Matsuyama T (2004) Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J Clin Invest 114(3):330–338

    PubMed  CAS  Google Scholar 

  87. Templin C, Kotlarz D, Faulhaber J, Schnabel S, Grote K, Salguero G, Luchtefeld M, Hiller KH, Jakob P, Naim HY, Schieffer B, Hilfiker-Kleiner D, Landmesser U, Limbourg FP, Drexler H (2008) Ex vivo expanded hematopoietic progenitor cells improve cardiac function after myocardial infarction: role of beta-catenin transduction and cell dose. J Mol Cell Cardiol 45(3):394–403

    Article  PubMed  CAS  Google Scholar 

  88. Tse HF, Kwong YL, Chan JK, Lo G, Ho CL, Lau CP (2003) Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet 361(9351):47–49

    Article  PubMed  Google Scholar 

  89. Turko IV, Murad F (2002) Protein nitration in cardiovascular diseases. Pharmacol Rev 54(4):619–634

    Article  PubMed  CAS  Google Scholar 

  90. Vahedi K, Hofmeijer J, Juettler E, Vicaut E, George B, Algra A, Amelink GJ, Schmiedeck P, Schwab S, Rothwell PM, Bousser MG, van der Worp HB, Hacke W (2007) Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol 6(3):215–222

    Article  PubMed  Google Scholar 

  91. van de Ven C, Collins D, Bradley MB, Morris E, Cairo MS (2007) The potential of umbilical cord blood multipotent stem cells for nonhematopoietic tissue and cell regeneration. Exp Hematol 35(12):1753–1765

    Article  PubMed  CAS  Google Scholar 

  92. Vendrame M, Gemma C, de Mesquita D, Collier L, Bickford PC, Sanberg CD, Sanberg PR, Pennypacker KR, Willing AE (2005) Anti-inflammatory effects of human cord blood cells in a rat model of stroke. Stem Cells Dev 14(5):595–604

    Article  PubMed  CAS  Google Scholar 

  93. Wechsler LR (2009) Clinical trials of stroke therapy: which cells, which patients? Stroke 40(3 Suppl):S149–S151

    Article  PubMed  Google Scholar 

  94. Willems L, Zatta A, Holmgren K, Ashton KJ, Headrick JP (2005) Age-related changes in ischemic tolerance in male and female mouse hearts. J Mol Cell Cardiol 38(2):245–256

    Article  PubMed  CAS  Google Scholar 

  95. Wu ZK, Tarkka MR, Pehkonen E, Kaukinen L, Honkonen EL, Kaukinen S (2000) Beneficial effects of ischemic preconditioning on right ventricular function after coronary artery bypass grafting. Ann Thorac Surg 70(5):1551–1557

    Article  PubMed  CAS  Google Scholar 

  96. Xu L, Eu JP, Meissner G, Stamler JS (1998) Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. Science 279(5348):234–237

    Article  PubMed  CAS  Google Scholar 

  97. Zairis MN, Lyras AG, Makrygiannis SS, Psarogianni PK, Adamopoulou EN, Handanis SM, Papantonakos A, Argyrakis SK, Prekates AA, Foussas SG (2004) Type 2 diabetes and intravenous thrombolysis outcome in the setting of ST elevation myocardial infarction. Diabetes Care 27(4):967–971

    Article  PubMed  Google Scholar 

  98. Zhang RL, Zhang ZG, Chopp M (2005) Neurogenesis in the adult ischemic brain: generation, migration, survival, and restorative therapy. Neuroscientist 11(5):408–416

    Article  PubMed  CAS  Google Scholar 

  99. Zhang X, Patel A, Horibe H, Wu Z, Barzi F, Rodgers A, MacMahon S, Woodward M (2003) Cholesterol, coronary heart disease, and stroke in the Asia Pacific region. Int J Epidemiol 32(4):563–572

    Article  PubMed  CAS  Google Scholar 

  100. Zorov DB, Juhaszova M, Sollott SJ (2006) Mitochondrial ROS-induced ROS release: an update and review. Biochim Biophys Acta 1757(5–6):509–517

    PubMed  CAS  Google Scholar 

  101. Zou M, Martin C, Ullrich V (1997) Tyrosine nitration as a mechanism of selective inactivation of prostacyclin synthase by peroxynitrite. Biol Chem 378(7):707–713

    Article  PubMed  CAS  Google Scholar 

  102. Zweier JL, Flaherty JT, Weisfeldt ML (1987) Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proc Natl Acad Sci USA 84(5):1404–1407

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

This work was supported in part by National Institutes of Health grants, K01 AR054114 (NIAMS), SBIR R44 HL092706-01 (NHLBI), R21 CA143787 (NCI) and The Ohio State University start-up fund. The funders had no role in study design, data collection and ­analysis, decision to publish or preparation of the manuscript.

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  1. Cardiovascular Stem Cell Research Laboratory, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 460 W. 12th Avenue, BRT 382, Columbus, OH, 43210, USA

    Suman Kanji, Vincent J. Pompili & Hiranmoy Das Ph.D.

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  3. Hiranmoy Das Ph.D.
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Correspondence to Hiranmoy Das Ph.D. .

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  1. , Pharmacology and Toxicology, University of Kansas Medical Center, Rainbow Blvd 3901, Kansas City, 66160, Kansas, USA

    Rakesh Srivastava

  2. , Pathology and Laboratory Medicine, University of Kansas Medical Center, Rainbow Blvd 3901, Kansas City, 66160, Kansas, USA

    Sharmila Shankar

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© 2012 Springer Science+Business Media B.V.

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Kanji, S., Pompili, V.J., Das, H. (2012). Ischemia, Reactive Radicals, Redox Signaling and Hematopoietic Stem Cells. In: Srivastava, R., Shankar, S. (eds) Stem Cells and Human Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2801-1_9

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