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The Biology of Lung Cancer Stem Cells

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Stem Cells and Human Diseases

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Abstract

Lung cancer is strongly correlated with tobacco smoking and causes the maximum number of cancer related deaths in the world. While there are many plausible models for the genesis and metastasis of cancers, the recently evolved cancer stem cell model offers new insights into the potential mechanisms underlying the development of cancer. According to this model, cancers can only be originated from a subset of the cells, which have the ability to self-renew and differentiate into the heterogeneous lineages of cancer cells. These cells are thought to have originated as a result of oncogenic transformation of the normal stem cells or its progenitor cells. The site of origin of various types of lung cancers coincides with specifically localized airway stem cell niches in murine models and therefore supports the stem cell origin of lung cancer. Various functional and cell surface markers have been used to identify and characterize lung cancer stem cells within the tumors; however, the clinical significance of these markers remains to be confirmed. Understanding the molecular mechanisms governing the deregulated self-renewal of these cells may identify novel therapeutic targets to combat lung cancer. This chapter describes the current state of knowledge of the biology of putative lung cancer stem cells.

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Acknowledgements

The studies in the Chellappan lab are supported by the grants CA127725 and CA139612 from the NCI.

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  1. Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, SRB3, Tampa, FL, 33612, USA

    Sandeep Singh & Srikumar P. Chellappan

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Correspondence to Srikumar P. Chellappan .

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    Rakesh Srivastava

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    Sharmila Shankar

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Singh, S., Chellappan, S.P. (2012). The Biology of Lung Cancer Stem Cells. In: Srivastava, R., Shankar, S. (eds) Stem Cells and Human Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2801-1_24

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