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Nutraceuticals in Human Urinary Bladder Cancer Prevention and Treatment

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Nutraceuticals and Cancer

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Abstract

Bladder cancer is a major public health burden. Tumor resection with possible intravesical treatments for superficial disease, and cystectomy or chemotherapy with radiation protocols for invasive bladder cancer have associated limitations and large costs. In addition, exposure to carcinogens contributes to the majority of bladder cancer risk. All of these represent profound opportunities to use nutraceuticals for improvement of current bladder cancer prevention and treatment. We discuss the clinical opportunities for use of nutraceuticals in bladder cancer prevention and treatment, including preventing the first occurrence of bladder cancer in high risk populations, delaying progression of the disease, use in combination with existing intravesical agents, and delaying or preventing radical cystectomy. We review randomized controlled trials of nutraceuticals in bladder cancer, current promising chemopreventive agents under preclinical development for bladder cancer prevention, and future directions of bladder cancer chemoprevention, including the concept of individualized bladder cancer chemoprevention.

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Abbreviations

4HRP:

N-4-hydroxyphenylretinamide

5-ALA:

5-aminolevulinic acid

ATBC:

alpha-Tocopherol Beta-Carotene

CIS:

carcinoma in situ

CPS-II:

cancer prevention study II

EMT:

epithelial-to-mesenchymal transformation

NMIBC:

non-muscle-invasive bladder cancers

RDA:

recommended daily allowance

RTK:

the receptor tyrosine kinases

TCC:

transitional cell carcinoma

TURBT:

transurethral resection of bladder tumor

UC:

urothelial carcinoma

UVB:

ultraviolet B

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Acknowledgments

Work cited from our laboratory was supported by NIH award 5R01CA122558-03 and 1R21CA152804-01A1 (to X. Z.).

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Authors and Affiliations

  1. Departments of Urology and Pharmaceutical Sciences, Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA, 92868, USA

    Xiaolin Zi

  2. Departments of Urology and Pharmaceutical Sciences, University of California, Irvine, Orange, CA, 92868, USA

    Christopher Blair

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  1. Xiaolin Zi
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Correspondence to Xiaolin Zi .

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Editors and Affiliations

  1. , Barbara Ann Karmanos Cancer Institute, Department of Pathology, John R Street, Detroit, 48201, USA

    Fazlul H. Sarkar

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Zi, X., Blair, C. (2012). Nutraceuticals in Human Urinary Bladder Cancer Prevention and Treatment. In: Sarkar, F. (eds) Nutraceuticals and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2630-7_8

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