Abstract
The diagnostic sensitivity of transrectal ultrasonography (TRUS) of the prostate is not sufficient for definitive diagnosis of prostatic cancer. Prostatic cancer sometimes appears as low intensity echo but it sometimes appears as isointensity echo as normal prostate. Thus, precise ultrasonic information rather than ultrasonic intensity is needed for further diagnosis. In the present study, ultrasonic properties of prostatic tissue are measured by ultrasound speed microscope (USM) and malignancy of the tissue is discussed. The sample obtained by radical prostatectomy was fixed by formalin and sliced as approximately 5 μm in thickness. One slice without staining was used for USM observation and the neighboring slice with Elastica-Masson staining was used for optical microscopic observation for comparison. In the prostatic cancer tissue, the sound speed of the poorly differentiated adenocarcinoma was 1,570 ± 8 m/s whereas as that of the well-differentiated adenocarcinoma was 1,660 ± 30 m/s. The sound speed measurement clearly classified the tissue type of prostatic cancer. As the imaging resolution is anti-proportional to the ultrasonic frequency, USM provides ten times higher resolution compared with TRUS. The basic acoustic information obtained by USM is useful for understanding clinical echo findings by TRUS.
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Acknowledgements
This project was supported in part by Grants-in-Aid for Scientific Research (Scientific Research (B) 22300175) from the Japan Society for the Promotion of Science, Sendai Advanced Preventive Health Care Services Cluster from the Ministry of Education, Culture, Sports, Science and Technology and Regional Innovation Program from the Ministry of Economy, Trade and Industry.
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Tanoue, H., Urata, Y., Hagiwara, Y., Saijo, Y. (2012). Sound Speed Measurement in Prostatic Cancer by Ultrasound Speed Microscope. In: Nowicki, A., Litniewski, J., Kujawska, T. (eds) Acoustical Imaging. Acoustical Imaging, vol 31. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2619-2_32
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DOI: https://doi.org/10.1007/978-94-007-2619-2_32
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