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Radiation Damage in Biomolecular Systems pp 301–311Cite as

Track-Structure Monte Carlo Modelling in X-ray and Megavoltage Photon Radiotherapy

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Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

The use of track structure calculations in radiotherapy using conventional low-LET radiation sources is discussed. Microdosimetry and emergent nanodosimetry methods are considered in explaining variations in quality factors associated with clinical practice and in vitro data. Transformation rate in the human derived for the in vitro system CGL1 is presented as a model for the induction of secondary cancer, a late effect associated with radiotherapy treatment.

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Acknowledgements

Frank Verhaegen is acknowledged for providing his thesis and the basic data on lineal energy spectra therein. Geoff Heyes, Alan Beddoe and Ihsan Al Affan are thanked for their helpful discussion.

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Authors and Affiliations

  1. College of Medicine, Swansea University, Swansea, SA2 8PP, UK

    Richard P. Hugtenburg

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  1. Richard P. Hugtenburg
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Correspondence to Richard P. Hugtenburg .

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Editors and Affiliations

  1. , Consejo Superior de Investigaciones Cien, Instituto de Física Fundamental (IFF), Serrano 113-bis, Madrid, 28006, Spain

    Gustavo García Gómez-Tejedor

  2. Consejo Superior de Investigaciones Cien, Instituto de Física Fundamental (IFF), Serrano 113bis, Madrid, 28006, Spain

    Martina Christina Fuss

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Hugtenburg, R.P. (2012). Track-Structure Monte Carlo Modelling in X-ray and Megavoltage Photon Radiotherapy. In: García Gómez-Tejedor, G., Fuss, M. (eds) Radiation Damage in Biomolecular Systems. Biological and Medical Physics, Biomedical Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2564-5_18

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  • DOI: https://doi.org/10.1007/978-94-007-2564-5_18

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-2563-8

  • Online ISBN: 978-94-007-2564-5

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