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Biomechanical ECM Switches and Tumor Metastasis

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Signaling Pathways and Molecular Mediators in Metastasis

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Abstract

Data is rapidly emerging that physical or biomechanical changes in extracellular matrix molecules (ECM) may allow differential control of cell signaling pathways and therefore, these structural alterations may actively regulate diverse cell types that comprise the tumor stroma. These mechanical changes in the structure of ECM molecules may trigger the exposure of cryptic ECM ­elements that help create a local microenvironment that facilitates initiation and progression of ­inflammation, tumor growth and metastasis. To this end, we will highlight the accumulating experimental evidence for the existence of biomechanical ECM switches and discuss how the selective triggering of these switches may be used by diverse cell types to promote malignant tumor progression. Finally, we will discuss ­scientific and clinical advancements that have lead to the recent translation of these exciting biological concepts into human clinical trials for cancer imaging and therapy.

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Acknowledgements

This work was supported in part from the National Institute of Health Grant CA91645 to PCB, The Maine Cancer Foundation (CPHV and PCB) and the National Institute of Health Center for Research Resources P20-RR-15555 (CPHV and PCB) and NIH Grant HL083151 (CPHV). Jacquelyn Ames is supported by the Integrative Graduate Education and Research Traineeship (NSF-IGERT DGE0221625) from UMaine. We would like to apologize to those investigators whose important work was not cited do to space limitations.

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  1. Maine Medical Center Research Institute, Center for Molecular Medicine, 81 Research Drive, Scarborough, ME, 04074, USA

    Jacquelyn J. Ames, Calvin P. H. Vary & Peter C. Brooks

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  1. Jacquelyn J. Ames
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  2. Calvin P. H. Vary
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  3. Peter C. Brooks
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Correspondence to Peter C. Brooks .

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  1. Drexel University College of Medicine, N. 15th Street 245, Philadelphia, 19102, Pennsylvania, USA

    Alessandro Fatatis

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Ames, J.J., Vary, C.P.H., Brooks, P.C. (2011). Biomechanical ECM Switches and Tumor Metastasis. In: Fatatis, A. (eds) Signaling Pathways and Molecular Mediators in Metastasis. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2558-4_3

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