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Signaling Pathways and Molecular Mediators in Metastasis pp 331–345Cite as

Tumor and Host Determinants of Pulmonary Metastasis in Bladder Cancer

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Abstract

Despite the recent advances in the diagnosis of bladder cancer, ­recurrence after surgical intervention for muscle invasive disease is still problematic as nearly half of patients harbor occult distant metastases. Clinical data from human disease revealed that, invasive and metastatic bladder cancer cells can metastasize to lungs, and this in turn is associated with poor 5-year survival rate. Experimental rodent models of carcinogenesis and metastasis are available to study this phenomenon. Comparative gene expression profiling, proteomic and computational studies identified an intertwined network of metastasis promoters and suppressors that modulate the interactions between the components of the pulmonary milieu and cancer cells inflammatory mediators, ECM molecules, as well as peptide hormones. In this chapter we provide select exemplar of some of the molecular mechanisms underlying lung colonization by bladder cancer.

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Authors and Affiliations

  1. Department of Urology, Paul Mellon Urologic Cancer Institute, University of Virginia, Charlottesville, VA, 22908, USA

    Neveen Said

  2. Departments of Surgery and Pharmacology, University of Colorado Comprehensive Cancer Center, Aurora, CO, 80045, USA

    Dan Theodorescu

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  1. Neveen Said
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  2. Dan Theodorescu
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Correspondence to Dan Theodorescu .

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  1. Drexel University College of Medicine, N. 15th Street 245, Philadelphia, 19102, Pennsylvania, USA

    Alessandro Fatatis

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Said, N., Theodorescu, D. (2011). Tumor and Host Determinants of Pulmonary Metastasis in Bladder Cancer. In: Fatatis, A. (eds) Signaling Pathways and Molecular Mediators in Metastasis. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2558-4_14

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