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Surface-Enhanced Raman Spectroscopy of Organic Molecules Adsorbed on Metallic Nanoparticles

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Nano-Biotechnology for Biomedical and Diagnostic Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 733))

Abstract

The improvements in Raman instrumentation have led to the development of ­portable, simple to operate, Raman instruments that can be used for on-site analysis of substances relevant for homeland security purposes such as chemical and biological warfare and explosives materials.

Raman spectroscopy, however, suffers from limited sensitivity which can be overcome by Surface-Enhanced Raman Spectroscopy (SERS). SERS can enhance the Raman signal of a target molecule by 6–10 orders of magnitude. The increased sensitivity, together with Raman’s molecular recognition capabilities and the availability of portable Raman instruments make SERS a powerful analytical tool for on site detection.

In this work we studied the effect of target molecules and SERS-active substrate properties on the obtained SERS, using a field portable Raman spectrometer. Also reported herein is the SERS detection of the chemical warfare agent sulfur mustard (HD, 2,2 dichloroethyl sulfide). This study may serve as a basis for the development of SERS platform for homeland security purposes.

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Authors and Affiliations

  1. Department of Physical Chemistry, Israel Institute for Biological Research, 19, Ness-Ziona, 74100, Israel

    Vered Heleg-Shabtai, Adi Zifman & Shai Kendler

Authors
  1. Vered Heleg-Shabtai
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  2. Adi Zifman
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  3. Shai Kendler
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Corresponding author

Correspondence to Vered Heleg-Shabtai .

Editor information

Editors and Affiliations

  1. Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona, 74100, Israel

    Eran Zahavy

  2. Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona, 74100, Israel

    Arie Ordentlich

  3. Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona, Israel

    Shmuel Yitzhaki

  4. Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona, 74100, Israel

    Avigdor Shafferman

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Heleg-Shabtai, V., Zifman, A., Kendler, S. (2012). Surface-Enhanced Raman Spectroscopy of Organic Molecules Adsorbed on Metallic Nanoparticles. In: Zahavy, E., Ordentlich, A., Yitzhaki, S., Shafferman, A. (eds) Nano-Biotechnology for Biomedical and Diagnostic Research. Advances in Experimental Medicine and Biology, vol 733. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2555-3_6

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