Abstract
We report on the deposition of triacetate-pullulan polysaccharide thin films on drug pellets (diclofenac sodium) by matrix assisted pulsed laser evaporation method. The radiation generated by a pulsed excimer KrF* laser source (λ = 248 nm, τ = 20 ns) operated at 2 Hz repetition rate was used for ice targets evaporation. The timed – controlled drug delivery was proved by spectroscopic in vitro studies and in vivo anti-inflammatory investigations on rabbits. We showed that the coating of drug pellets with triacetate-pullulan thin films resulted in the delayed delivery of the drug for up to 30 min.
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Acknowledgements
C.P, G.S. and I.N.M, acknowledge with thanks the financial support of this research by CNCSIS under the IDEI contract 511/16.01.2009.
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Cristescu, R. et al. (2012). Pulsed Laser Processing of Functionalized Polysaccharides for Controlled Release Drug Delivery Systems. In: Vaseashta, A., Braman, E., Susmann, P. (eds) Technological Innovations in Sensing and Detection of Chemical, Biological, Radiological, Nuclear Threats and Ecological Terrorism. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2488-4_25
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DOI: https://doi.org/10.1007/978-94-007-2488-4_25
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