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Neuroblastoma pp 199–207Cite as

Advanced Neuroblastoma: Role of ALK Mutations

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Part of the book series: Pediatric Cancer ((PECA,volume 1))

Abstract

Neuroblastoma is an embryonal tumor derived from primitive cells of the sympathetic nervous system and is one of the most common solid tumors in childhood. Despite the significant advances, high-risk neuroblastoma remains a therapeutic challenge for pediatric oncologists. Anaplastic lymphoma kinase (ALK) was initially identified as a fusion partner of the nucleophosmin (NPM) gene in anaplastic large cell lymphoma with t(2;5) (p23;q35) translocation, and recently, it was also reported to participate in the generation of EML4-ALK fusion in lung cancer. In addition, ALK has been shown to be mutated or amplified in most of familial neuroblastomas, as well as approximately 10% of sporadic neuroblastoma cases. Mutated kinases showed autophosphorylation with increased kinase activity compared with wild-type kinase, and were able to transform NIH3T3 fibroblasts as evaluated by in vivo tumor formation in nude mice. Therefore, the ALK signaling pathway contributes to neuroblastoma oncogenesis providing a highly interesting therapeutic target in a subset of neuroblastoma.

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Authors and Affiliations

  1. Department of Cell Therapy and Transplantation Medicine and Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, 113-8655, Japan

    Junko Takita

  2. Cancer Genomics Project, Graduate School of Medicine, University of Tokyo, Tokyo, 113-8655, Japan

    Seishi Ogawa

Authors
  1. Junko Takita
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  2. Seishi Ogawa
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Correspondence to Junko Takita .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Takita, J., Ogawa, S. (2012). Advanced Neuroblastoma: Role of ALK Mutations. In: Hayat, M. (eds) Neuroblastoma. Pediatric Cancer, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2418-1_19

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