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Oxidative DNA Damage Mediated by Transition Metal Ions and Their Complexes

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Interplay between Metal Ions and Nucleic Acids

Part of the book series: Metal Ions in Life Sciences ((MILS,volume 10))

Abstract

DNA damage by redox-active metal complexes depends on the interaction of the metal complex with DNA together with the mechanism of oxygen activation. Weak interaction, tight binding, and direct involvement of DNA in the coordination sphere of the metal are described. Metal complexes acting through the production of diffusing radicals and metal complexes oxidizing DNA by metal-centered active species are compared. Metal complexes able to form high-valent metal-oxo species in close contact with DNA and perform DNA oxidation in a way reminiscent of enzymatic chemistry are the most elegant systems.

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Acknowledgments

The contribution of coauthors whose names appear in the references is acknowledged. This article is dedicated to Dr Marguerite Pitié.

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Authors and Affiliations

  1. Laboratoire de Chimie de Coordination, CNRS, 205, Route de Narbonne, F-31077, Toulouse-Cedex 04, France

    Geneviève Pratviel

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  1. Geneviève Pratviel
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Correspondence to Geneviève Pratviel .

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Editors and Affiliations

  1. Inorganic Chemistry, Chemistry, Universität Basel, Spitalstr. 51, Basel, 4056, Basel Stadt, Switzerland

    Astrid Sigel

  2. Inorganic Chemistry, Chemistry, Universität Basel, Spitalstr. 51, Basel, 4056, Basel Stadt, Switzerland

    Helmut Sigel

  3. Organisch-Chemisches Institut, Universität Zürich, Winterthurerstrasse 190, Zürich, 8057, Switzerland

    Roland K. O. Sigel

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Pratviel, G. (2012). Oxidative DNA Damage Mediated by Transition Metal Ions and Their Complexes. In: Sigel, A., Sigel, H., Sigel, R. (eds) Interplay between Metal Ions and Nucleic Acids. Metal Ions in Life Sciences, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2172-2_7

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