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Astrocytomas: Predicting Survival and Recurrence Using Cerebral Blood Volume Measurements

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Tumors of the Central Nervous System, Volume 5

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 5))

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Abstract

Although histopathologic assessment remains the reference standard for determining the glioma grade and predicting survival, inherent shortcomings like sampling error, inter- and intrapathologist variability, and difference in biology within WHO grades of astrocytomas may result in inadequate evaluation of the entire tumor. Thus, imaging studies and specifically, cerebral blood volume (CBV) measurements may provide information in addition to the pathologic assessment and improve grading as well as have predictive value for survival and recurrence. Various studies suggest that the tumor relative CBV (rCBV) on pretreatment MR imaging is an independent stronger than the degree of enhancement predictor of survival in patients with low- and high-grade astrocytomas. Moreover, rCBV measurements have been shown to be more significant than histopathological grade for the prediction of progression-free survival even among patients with astrocytomas of the same histologic grade. Finally, the combined assessment of histopathologic and perfusion MR imaging findings seems to surpass the individual methods and may be useful to determine optimal management strategies in patients with astrocytomas.

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Authors and Affiliations

  1. Department of Diagnostic and Interventional Neuroradiology, Karls Eberhard University, Tübingen, Germany

    Sotirios Bisdas

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  1. Sotirios Bisdas
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Correspondence to Sotirios Bisdas .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Bisdas, S. (2012). Astrocytomas: Predicting Survival and Recurrence Using Cerebral Blood Volume Measurements. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 5. Tumors of the Central Nervous System, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2019-0_24

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  • DOI: https://doi.org/10.1007/978-94-007-2019-0_24

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-2018-3

  • Online ISBN: 978-94-007-2019-0

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