Abstract
Adipose-derived stem cells (ASCs) are equally capable of differentiating into multiple lineages compared with bone marrow-derived stem cells. Because human adipose tissue can be easily obtained in large quantities under local anesthesia with little patient discomfort, it may provide an alternative source of stem cells for mesenchymal tissue regeneration and engineering. On the other hand, platelet-rich plasma (PRP) contains a high concentration of thrombocytes. In α-granules of platelets, there are platelet-released growth factors that include molecules such as platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-β, which stimulate cell proliferation and differentiation, including those of ASCs for tissue regeneration. ASCs and PRP can be used for clinical cases without concerns for infection and immunological rejection because these are autologous tissue and blood. The efficacy of combination therapy using these has been increasingly recognized in the fields of wound healing, fat grafting, and periodontal tissue regeneration.
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Kakudo, N., Kushida, S., Kusumoto, K. (2012). Adipose-Derived Stem Cells and Platelet-Rich Plasma: Implications for Regenerative Medicine. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 2. Stem Cells and Cancer Stem Cells, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2016-9_34
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DOI: https://doi.org/10.1007/978-94-007-2016-9_34
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