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Adult Neurogenesis in Etiology and Pathogenesis of Alzheimer’s Disease

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Stem Cells and Cancer Stem Cells, Volume 2

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 2))

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Abstract

The adult brain of mammals has the potential to self-repair and regenerate. Adult neurogenesis is enhanced in the hippocampus and reduced in the subventricular zone (SVZ) of patients with Alzheimer’s disease (AD). Enhanced neurogenesis in the hippocampus of AD patients suggests a regenerative attempt to compensate for the neuronal loss, whereas reduced neurogenesis in the SVZ would contribute to pathological processes associated with the disease, such as anosmia. Neurogenesis has the potential to generate aneuploid neuronal cells in the adult brain. Adult neurogenesis and neural stem cells (NSCs) would thus contribute both beneficially and detrimentally to the pathology of AD. Adult neurogenesis and NSCs are as important for our understanding of the development of the nervous system and for therapy, as for our understanding of the etiology and pathogenesis of neurological diseases, particularly AD. The understanding of which will lead to novel treatments and therapies for neurological diseases and injuries.

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References

  • Anderson DH, Talaga KC, Rivest AJ, Barron E, Hageman GS, Johnson LV (2004) Characterization of beta amyloid assemblies in drusen: The deposits associated with aging and age-related macular degeneration. Exp Eye Res 78:243–256

    Article  PubMed  CAS  Google Scholar 

  • Bertram L, Tanzi RE (2008) Thirty years of Alzheimer’s disease genetics: the implications of systematic meta-analyses. Nat Rev Neurosci 9:768–778

    Article  PubMed  CAS  Google Scholar 

  • Boeras DI, Granic A, Padmanabhan J, Crespo NC, Rojiani AM, Potter H (2008) Alzheimer’s presenilin 1 causes chromosome missegregation and aneuploidy. Neurobiol Aging 29:319–328

    Article  PubMed  CAS  Google Scholar 

  • Brown AB, Yang W, Schmidt NO, Carroll R, Leishear KK, Rainov NG, Black PM, Breakefield XO, Aboody KS (2003) Intravascular delivery of neural stem cell lines to target intracranial and extracranial tumors of neural and non-neural origin. Hum Gene Ther 14:1777–1785

    Article  PubMed  CAS  Google Scholar 

  • Brun A, Gustafson L (1976) Distribution of cerebral degeneration in Alzheimer’s disease. A clinico-pathological study. Arch Psychiatr Nervenkr 223:15–33

    Article  CAS  Google Scholar 

  • Brundin P, Barker RA, Parmar M (2010) Neural grafting in Parkinson’s disease: Problems and possibilities. Progr Brain Res 184:265–294

    Article  Google Scholar 

  • Burns A, Byrne EJ, Maurer K (2002) Alzheimer’s disease. Lancet 13:163–165

    Article  Google Scholar 

  • Busser J, Geldmacher DS, Herrup K (1998) Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer’s disease brain. J Neurosci 18:2801–2807

    PubMed  CAS  Google Scholar 

  • Cameron HA, Woolley CS, McEwen BS, Gould E (1993) Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience 56:337–344

    Article  PubMed  CAS  Google Scholar 

  • Curtis MA, Kam M, Nannmark U, Anderson MF, Axell MZ, Wikkelso C, Holtas S, van Roon-Mom WM, Bjork-Eriksson T, Nordborg C, Frisen J, Dragunow M, Faull RL, Eriksson PS (2007) Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension. Science 315:1243–1249

    Article  PubMed  CAS  Google Scholar 

  • Duan X, Kang E, Liu CY, Ming GL, Song H (2008) Development of neural stem cell in the adult brain. Curr Opin Neurobiol 18:108–115

    Article  PubMed  CAS  Google Scholar 

  • Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, Meguro K, O’brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P (2007) Research criteria for the diagnosis of Alzheimer’s disease: Revising the NINCDS–ADRDA criteria. Lancet Neurol 6:734–746

    Article  PubMed  Google Scholar 

  • Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH (1998) Neurogenesis in the adult human hippocampus. Nat Med 4:1313–1317

    Article  PubMed  CAS  Google Scholar 

  • Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M, Alzheimer’s Disease International (2005) Global prevalence of dementia: A Delphi consensus study. Lancet 366:2112–2117

    Article  PubMed  Google Scholar 

  • Filipcik P, Cente M, Ferencik M, Hulin I, Novak M (2006) The role of oxidative stress in the pathogenesis of Alzheimer’s disease. Bratisl Lek Listy 107:384–394

    PubMed  CAS  Google Scholar 

  • Fukutani Y, Kobayashi K, Nakamura I, Watanabe K, Isaki K, Cairns NJ (1995) Neurons, intracellular and extra cellular neurofibrillary tangles in subdivisions of the hippocampal cortex in normal ageing and Alzheimer’s disease. Neurosci Lett 200:57–60

    Article  PubMed  CAS  Google Scholar 

  • Fusetti M, Fioretti AB, Silvagni F, Simaskou M, Sucapane P, Necozione S, Eibenstein A (2010) Smell and preclinical Alzheimer disease: Study of 29 patients with amnesic mild cognitive impairment. J Otolaryngol Head Neck Surg 39:175–181

    PubMed  Google Scholar 

  • Gage FH (2000) Mammalian neural stem cells. Science 287:1433–1438

    Article  PubMed  CAS  Google Scholar 

  • Goldgaber D, Lerman MI, McBride OW, Saffiotti U, Gajdusek DC (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer’s disease. Science 235:877–880

    Article  PubMed  CAS  Google Scholar 

  • Gould E, Gross GC (2002) Neurogenesis in adult mammals: some progress and problems. J Neurosci 22:619–623

    PubMed  CAS  Google Scholar 

  • Herrup K, Arendt T (2002) Re-expression of cell cycle proteins induces neuronal cell death during Alzheimer’s disease. J Alzheimer’s Dis 4:243–247

    CAS  Google Scholar 

  • Iqbal K, Liu F, Gong CX, Alonso Adel C, Grundke-Iqbal I (2009) Mechanisms of tau-induced neurodegeneration. Acta Neuropathol 118:53–69

    Article  PubMed  CAS  Google Scholar 

  • Jin K, Peel AL, Mao XO, Xie L, Cottrell BA, Henshall DC, Greenberg DA (2004a) Increased hippocampal neurogenesis in Alzheimer’s disease. Proc Natl Acad Sci USA 101:343–347

    Article  PubMed  CAS  Google Scholar 

  • Jin K, Galvan V, Xie L, Mao XO, Gorostiza OF, Bredesen DE, Greenberg DA (2004b) Enhanced neurogenesis in Alzheimer’s disease transgenic (PDGF-APPSw,Ind) mice. Proc Natl Acad Sci USA 101:13363–13367

    Article  PubMed  CAS  Google Scholar 

  • Kaneko Y, Sakakibara S, Imai T, Suzuki A, Nakamura Y, Sawamoto K, Ogawa Y, Toyama Y, Miyata T, Okano H (2000) Musashi1: an evolutionally conserved marker for CNS progenitor cells including neural stem cells. Dev Neurosci 22:139–153

    Article  PubMed  CAS  Google Scholar 

  • Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Müller-Hill B (1987) The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733–736

    Article  PubMed  CAS  Google Scholar 

  • Kempermann G, Kuhn HG, Gage FH (1997) More hippocampal neurons in adult mice living in an enriched environment. Nature 386:493–495

    Article  PubMed  CAS  Google Scholar 

  • Kim H, Jensen CG, Rebhun LI (1986) The binding of MAP-2 and tau on brain microtubules in vitro: Implications for microtubule structure. Ann NY Acad Sci 466:218–239

    Article  PubMed  CAS  Google Scholar 

  • Kingsbury MA, Yung YC, Peterson SE, Westra JW, Chun J (2006) Aneuploidy in the normal and diseased brain. Cell Mol Life Sci 63:2626–2641

    Article  PubMed  CAS  Google Scholar 

  • Komitova M, Eriksson PS (2004) Sox-2 is expressed by neural progenitors and astroglia in the adult rat brain. Neurosci Lett 369:24–27

    Article  PubMed  CAS  Google Scholar 

  • Lendahl U, Zimmerman LB, McKay RD (1990) CNS stem cells express a new class of intermediate filament protein. Cell 60:585–595

    Article  PubMed  CAS  Google Scholar 

  • Li J, Xu M, Zhou H, Ma J, Potter H (1997) Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell 90:917–927

    Article  PubMed  CAS  Google Scholar 

  • Li W, Howard JD, Gottfried JA (2010) Disruption of odour quality coding in piriform cortex mediates olfactory deficits in Alzheimer’s disease. Brain 133:2714–2726

    Article  PubMed  Google Scholar 

  • Lois C, Alvarez-Buylla A (1994) Long-distance neuronal migration in the adult mammalian brain. Science 264:1145–1148

    Article  PubMed  CAS  Google Scholar 

  • Migliore L, Botto N, Scarpato R, Petrozzi L, Cipriani G, Bonuccelli U (1999) Preferential occurrence of chromosome 21 malsegregation in peripheral blood lymphocytes of Alzheimer disease patients. Cytogenet Cell Genet 87:41–46

    Article  PubMed  CAS  Google Scholar 

  • Miller MW, Nowakowski RS (1998) Use of bromodeoxyuridine-immunohistochemistry to examine the proliferation, migration and time of origin of cells in the central nervous system. Brain Res 457:44–52

    Article  Google Scholar 

  • Newman M, Musgrave FI, Lardelli M (2007) Alzheimer disease: amyloidogenesis, the presenilins and animal models. Biochim Biophys Acta 1772:285–297

    Article  PubMed  CAS  Google Scholar 

  • Nishimura M, Yu G, St George-Hyslop PH (1999) Biology of presenilins as causative molecules for Alzheimer disease. Clin Genet 55:219–225

    Article  PubMed  CAS  Google Scholar 

  • Okuda T, Tagawa K, Qi ML Hoshio M, Ueda H, Kawano H, Kanazawa I, Muramatsu M, Okazawa H (2004) Oct-3/4 repression accelerates differentiation of neural progenitor cells in vitro and in vivo. Brain Res Mol Brain Res 132:18–30

    Article  PubMed  CAS  Google Scholar 

  • Palmer TD, Schwartz PH, Taupin P, Kaspar B, Stein SA, Gage FH (2001) Cell culture. Progenitor cells from human brain after death. Nature 411:42–43

    Article  PubMed  CAS  Google Scholar 

  • Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Dina G, Galli R, Del Carro U, Amadio S, Bergami A, Furlan R, Comi G, Vescovi AL, Martino G (2003) Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature 422:688–694

    Article  PubMed  CAS  Google Scholar 

  • Prasher VP, Haque MS (2000) Apolipoprotein E, Alzheimer’s disease and Down’s syndrome. Br J Psychiatry 177:469–470

    Article  PubMed  CAS  Google Scholar 

  • Querfurth HW, LaFerla FM (2010) Alzheimer’s disease. N Engl J Med 362:329–344

    Article  PubMed  CAS  Google Scholar 

  • Reynolds BA, Weiss S (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255:1707–1710

    Article  PubMed  CAS  Google Scholar 

  • Rodríguez JJ, Jones VC, Tabuchi M, Allan SM, Knight EM, LaFerla FM, Oddo S, Verkhratsky A (2008) Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer’s disease. PLoS One 3:e2935

    Article  PubMed  Google Scholar 

  • Sotthibundhu A, Li QX, Thangnipon W, Coulson EJ (2009) Abeta(1-42) stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor. Neurobiol Aging 30:1975–1985

    Article  PubMed  CAS  Google Scholar 

  • St George-Hyslop PH, Petit A (2005) Molecular biology and genetics of Alzheimer’s disease. C R Biol 328:119–130

    Article  PubMed  CAS  Google Scholar 

  • Taupin P (2007a) Protocols for studying adult neurogenesis: Insights and recent developments. Regener Med 2:51–62

    Article  CAS  Google Scholar 

  • Taupin P (2007b) BrdU immunohistochemistry for studying adult neurogenesis: Paradigms, pitfalls, limitations, and validation. Brain Res Rev 53:198–214

    Article  PubMed  CAS  Google Scholar 

  • Taupin P (2009a) Characterization and isolation of synapses of newly generated neuronal cells of the adult hippocampus at early stages of neurogenesis. J Neurodegener Regener 2:9–17

    Google Scholar 

  • Taupin P (2009b) Adult neurogenesis, neural stem cells and Alzheimer’s disease: Developments, limitations, problems and promises. Curr Alzheimer Res 6:461–470

    Article  PubMed  CAS  Google Scholar 

  • Taupin P (2010a) Ex vivo fucosylation to improve the engraftment capability and therapeutic potential of human cord blood stem cells. Drug Discov Today 15:698–699

    Article  PubMed  Google Scholar 

  • Taupin P (2010b) Transplantation of cord blood stem cells for treating hematologic diseases and strategies to improve engraftment. Therapy 7:703–715

    Article  Google Scholar 

  • Taupin P (2010c) Adult neurogenesis and neural stem cells as a model for the discovery and development of novel drugs. Expert Opin Drug Discov 5:921–925

    Article  PubMed  CAS  Google Scholar 

  • Taupin P (2010d) A dual activity of ROS and oxidative stress on adult neurogenesis and Alzheimer’s disease. Central Nervous SystAgents Med Chem 10:16–21

    Article  CAS  Google Scholar 

  • Taupin P, Gage FH (2002) Adult neurogenesis and neural stem cells of the central nervous system in mammals. J Neurosci Res 69:745–749

    Article  PubMed  CAS  Google Scholar 

  • Taupin P, Ray J, Fischer WH, Suhr ST, Hakansson K, Grubb A, Gage FH (2000) FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor. Neuron 28:385–397

    Article  PubMed  CAS  Google Scholar 

  • Toni N, Teng EM, Bushong EA, Aimone JB, Zhao C, Consiglio A, van Praag H, Martone ME, Ellisman MH, Gage FH (2007) Synapse formation on neurons born in the adult hippocampus. Nat Neurosci 10:727–734

    Article  PubMed  CAS  Google Scholar 

  • Wang JF, Lu R, Wang YZ (2010) Regulation of β cleavage of amyloid precursor protein. Neurosci Bull 26:417–427

    Article  PubMed  Google Scholar 

  • Wang XP, Ding HL (2008) Alzheimer’s disease: Epidemiology, genetics, and beyond. Neurosci Bull 24:105–109

    Article  PubMed  Google Scholar 

  • Yang Y, Herrup K (2007) Cell division in the CNS: Protective response or lethal event in post-mitotic neurons? Biochim Biophys Acta 1772:457–466

    Article  PubMed  CAS  Google Scholar 

  • Yang Y, Geldmacher DS, Herrup K (2001) DNA replication precedes neuronal cell death in Alzheimer’s disease. J Neurosci 21:2661–2668

    PubMed  CAS  Google Scholar 

  • Yang Y, Mufson EJ, Herrup K (2003) Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer’s disease. J Neurosci 23:2557–2563

    PubMed  CAS  Google Scholar 

  • Yu Y, He J, Zhang Y, Luo H, Zhu S, Yang Y, Zhao T, Wu J, Huang Y, Kong J, Tan Q, Li XM (2009) Increased hippocampal neurogenesis in the progressive stage of Alzheimer’s disease phenotype in an APP/PS1 double transgenic mouse model. Hippocampus 19:1247–1253

    Article  PubMed  Google Scholar 

  • Zhang C, McNeil E, Dressler L, Siman R (2007) Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer’s disease. Exp Neurol 204:77–87

    Article  PubMed  CAS  Google Scholar 

  • Ziabreva I, Perry E, Perry R, Minger SL, Ekonomou A, Przyborski S, Ballard C (2006) Altered neurogenesis in Alzheimer’s disease. J Psychosom Res 61:311–316

    Article  PubMed  Google Scholar 

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  1. School of Biotechnology, Dublin City University, Dublin 9, Ireland

    Philippe Taupin

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  1. Philippe Taupin
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Correspondence to Philippe Taupin .

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    M.A. Hayat

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Taupin, P. (2012). Adult Neurogenesis in Etiology and Pathogenesis of Alzheimer’s Disease. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 2. Stem Cells and Cancer Stem Cells, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2016-9_27

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