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Implications of Cytokines in Cochlear Pathophysiology

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Mechanical Stretch and Cytokines

Part of the book series: Mechanosensitivity in Cells and Tissues ((MECT,volume 5))

Abstract

The cochlea is a mechanosensitive organ that perceives sounds. Hair cells with mechanosensitive transducer channels are the sensory cells of hearing. The stria vascularis generates specific electrochemical gradients of potassium and an endocochlear potential that are needed for the mechanoelectrical transduction of hair cells. Spiral ganglion neurons form the VIIIth cranial nerve and conduct action potentials. So far, little is known about the effects of cytokines/chemokines on the cochlear physiology in auditory perception. Recent reports have clarified the involvements of cytokines in the death of cochlear cells in various cochlear injuries. On the other hand, neurotrophic factors play key roles in the development and maintenance of spiral ganglion neurons. This review summarizes what is currently known about the involvement of cytokines in cochlear pathophysiology.

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Acknowledgement

This work was supported by a Grant-in-aid for Scientific Research ((C) 20591969) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

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Authors and Affiliations

  1. Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 305-8575, Japan

    Keiji Tabuchi & Akira Hara

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  1. Keiji Tabuchi
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  2. Akira Hara
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Correspondence to Keiji Tabuchi .

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Editors and Affiliations

  1. Dept. Fundamental &, Applied Physiology, Russian State Medical University, Ostrovitjanova Str. 1, Moskva, 117997, Russian Federation

    Andre Kamkin

  2. , Department of Fundamental and Applied Ph, Russian State Medical University, Ostrovitjanova Str. 1, Moscow, 117997, Russian Federation

    Irina Kiseleva

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Tabuchi, K., Hara, A. (2012). Implications of Cytokines in Cochlear Pathophysiology. In: Kamkin, A., Kiseleva, I. (eds) Mechanical Stretch and Cytokines. Mechanosensitivity in Cells and Tissues, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2004-6_8

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