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Low Dose Responses of Bone Marrow to X-Rays In Vivo

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Radiobiology and Environmental Security

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Abstract

Radiation risk at low doses is determined by linear extrapolation from high dose epidemiological data. In the last decade many non-targeted effects have been reported which may be relevant to low dose risk determination. To investigate cell responses at such low doses we used bone marrow cells of mice. We have not observed non-targeted effects long- or short-term post irradiation. Exposure below 50–100 mGy provides no evidence of a dose response for apoptotic signaling, bystander effects and low responses for p53 and p21 induction with significant individual variability. There is also no evidence for long-term chromosomal instability in the bone marrow at doses below 1 Gy. The data also demonstrate unexpected thresholds above which dose-dependent damage signaling is observed and the chromosomal instability phenotype is induced. The data are consistent with low dose X-irradiation being less damaging than would be expected from the LNT paradigm.

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Acknowledgements

This work was supported by the NOTE IP 036465 (FI6R), Euratom specific programme for research and training on nuclear energy, 6th FP of the EC and by a specialist programme 07003 of Leukaemia and Lymphoma Research.

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Authors and Affiliations

  1. Centre for Oncology and Molecular Medicine, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK

    Nikolay A. Zyuzikov

  2. University of Dundee, Dundee, DD1 9SY, Scotland, UK

    Nikolay A. Zyuzikov, Philip J. Coates, Sally A. Lorimore & Eric G. Wright

Authors
  1. Nikolay A. Zyuzikov
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  2. Philip J. Coates
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  3. Sally A. Lorimore
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  4. Eric G. Wright
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Corresponding author

Correspondence to Nikolay A. Zyuzikov .

Editor information

Editors and Affiliations

  1. , Medical Physics, McMaster University, Main Street West 1280, Hamilton, L8S 4 K1, Canada

    Carmel E. Mothersill

  2. Joint Institute for Nuclear Research, Dubna, Moscow Region, 141980, Russian Federation

    Victoria Korogodina

  3. , Department of Medical Physics, McMaster University, Main Street West 1280, Hamilton, L8S 4K1, Canada

    Colin B. Seymour

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Zyuzikov, N.A., Coates, P.J., Lorimore, S.A., Wright, E.G. (2012). Low Dose Responses of Bone Marrow to X-Rays In Vivo. In: Mothersill, C., Korogodina, V., Seymour, C. (eds) Radiobiology and Environmental Security. NATO Science for Peace and Security Series C: Environmental Security. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1939-2_13

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