Abstract
It was shown that mice or rats exposed to sublethal dose of ionizing radiation are able to decrease the immune reactivity of intact animals when them kept together in the same cage. Even one individual can cause such a disturbances of immunity in a group of intact animals. The data indicate that at early stage after exposure to sublethal doses of ionizing radiation mice secrete volatile components (VC) in urine which decreased thymus dependent humoral immune response in intact animals (to 60–70% relative control). The stable effect observed as a result of 1-day exposure allowed us to study the time course of secretion of immunosuppressive VC by irradiated animals. These VC possess attractive properties for the intact individuals. The irradiated mice showed an increased attractiveness to intact individuals. The biological significance of a combination of the immunosuppressive and attractive effects of VC is unclear. It is supposed, that mammals possess of the distant immunomodulating chemosignal system, aimed at the immunoreactivity of individuals with immunodeficiency state.
It was established that VC of intact mice restored the humoral immune response and other parameters of immunity in irradiated with a dose of 1 Gy animals. In this case, the irradiated recipients demonstrated an increase of humoral immune response to 140–170%. These VC of intact mice activated at irradiation mice phagocytic activity peritoneal macrophages. Exposure of rats for the third day after irradiation (1 Gy) to the VC of intact animals significantly increased the number of red blood cells, lymphocytes and granulocytes in the bloodstream.
Thus, direct and reverse bystander chemosignaling between the irradiated and intact, irradiated and irradiated animals mediate the modification of immunity and behavioral reactions of recipients. Apparently these untargeted effects of radiation spreading from one individual to another can have a significant impact on the viability of the entire population of animals.
This work was supported by the Russian Foundation for Basic Research and the Government of Kaluga Region project No 09-04-97505.
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References
Beauchamp GK, Yamazaki K (2003) Chemical signaling in mice. Biochem Soc Trans 31:147–151
Brennan PA, Kendrick KM (2006) Mammalian social odours: attraction and individual recognition. Philos Trans R Soc Lond B Biol Sci 361(1476):206–278
Hurst JL, Beynon RJ (2004) Scent wars: the chemobiology of competitive signaling in mice. Bioessays 26(12):1288–1289
Kavaliers M, Colwell DD (1995) Odours of parasitized males induce aversive response in female mice. Anim Behav 50:1161–1169
Moshkin MP, Gerlinskaya L, Morosova O, Bakhvalova V, Evsikov V (2002) Behaviour, chemosignals and endocrine functions in male mice infected with tick-borne encephalitis virus. Psychoneuroendocrinology 27:603–608
Mothersill C, Seymour CB (2001) Radiation-induced bystander effects: past history and future directions. Radiat Res 155:759–67, Review
Mothersill C, Bucking C, Smith RW, Agnihotri N, O’Neill A, Kilemade M, Seymour CB (2007) Communication of radiation-induced stress or bystander signals between fish in vivo. Environ Sci Technol 41:3382–3387
Novikov SN (1988) Feromony i razmnozhenie mlekopitayushchikh (Pheromones and reproduction in mammals). Nauka, Leningrad
Penn DJ, Potts WK (1998) Chemical signals and parasite-mediated sexual selection. Trends Ecol Evol 13:391–396
Surinov BP (2007) Mice with radiation or toxic damage or malignant tumors produce aversive chemosignals repelling intact animals. Dokl Biol Sci 414:199–201
Surinov BP, Dukhova NN (2004) Postradiation mice’s volatile secretions which are attractive for intact individuals. Radiat Biol Radioecologiya 44(6):662–665, In Russian
Surinov BP, Isaeva VG, Dukhova NN (2005) Post-radiation immunosuppressing and attractive volatile secretions: “bystander effect” or allelopathy in groups of animals. Dokl Biol Sci 400(5):28–30
Surinov BP, Sharetsky AN, Shpagin DV, Isayeva VG, Dukhova NN (2007) Post-radiated and post-stressed volatile secretions: secondary immune and behavioral reactions in groups of animals. In: Mothersill C et al (eds.) Multiple stressors: a challenge for the future. Springer, Dordrecht, pp 127–138
Surinov BP, Isaeva VG, Karpova NA (2008) Immunostimulating chemosignaling in animals with secondary immunodeficiency. Dokl Biol Sci 418:41–43
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Surinov, B.P., Isayeva, V.G., Sharetsky, A.N. (2012). Direct and Reverse Bystander Effect Between Irradiated and Unirradiated Organisms: The Modulating Role of Chemosignalling in Ecology. In: Mothersill, C., Korogodina, V., Seymour, C. (eds) Radiobiology and Environmental Security. NATO Science for Peace and Security Series C: Environmental Security. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1939-2_10
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