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Umblical Cord Blood and Alpha-3 Fucosyl Transferase-Treated Haematopoietic Stem Cells for Transplantation

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Stem Cells and Cancer Stem Cells, Volume 1

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 1))

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Abstract

The bone marrow (BM) and the umbilical cord are the main sources of haematopoietic stem cells (HSCs) for the treatment of malignant and non-malignant haematologic diseases. The umbilical cord blood (UCB) is a source of choice of HSCs for unrelated allogeneic transplantation. The transplantation of UCB for treating patients with haematologic diseases is associated with delayed engraftment, graft failure and a high rate of mortality and morbidity, particularly in adults. Strategies are being devised and considered to improve the rate of success of UCB transplantation. Patients are treated with double dose of UCB. The fucosylation of UCB ex vivo, prior transplantation, improves the homing and engraftment of UCB stem cells to the BM in rodents. The improvement of the homing and engraftment of UCB stem cells to the BM would overcome the major limitations of UCB for transplantation for the treatment of haematologic diseases. It would reduce the delay of engraftment of UCB stem cells to the BM, reduce the risk of early infections and improve the rate of success of UCB transplantation.

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Authors and Affiliations

  1. School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland

    Philippe Taupin

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  1. Philippe Taupin
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Correspondence to Philippe Taupin .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Taupin, P. (2012). Umblical Cord Blood and Alpha-3 Fucosyl Transferase-Treated Haematopoietic Stem Cells for Transplantation. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 1. Stem Cells and Cancer Stem Cells, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1709-1_19

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