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Role of MicroRNA in Glioma

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Tumors of the Central Nervous System, Volume 4

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 4))

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Abstract

Gliomas are the most common type of malignant primary brain tumors. Despite the advances in surgery, radiation therapy, and chemotherapy, the prognosis of patients with gliomas has not improved significantly. MicroRNAs (miRNAs) are a class of 21–25 nucleotide long, non-coding RNAs that negatively regulate the expression of target genes by interacting with specific sites of mRNA. They control a wide array of biological processes, including cell differentiation, proliferation, and apoptosis. Recent studies show that miRNAs are aberrant expressed in gliomas and play a critical role in the development of gliomas, indicating a novel way to investigate the tumorigenesis, diagnosis and therapy of gliomas. Here we focus on recent findings of miRNA study in gliomas to emphasize the important and new highlights of miRNA involved in gliomas.

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Acknowledgments

This work was supported by China National Natural Scientific Fund (81072078 and 30872657), Jiangsu Province’s Natural Science Foundation (BK2008475, 2010580), Program for Development of Innovative Research Team in the First Affiliated Hospital of NJMU, and Provincial Initiative Program for Excellency Disciplines, Jiangsu Province.

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Authors and Affiliations

  1. Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

    Yongping You, Ning Liu, Chunsheng Kang, Peiyu Pu & Zhen Fu

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  1. Yongping You
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  2. Ning Liu
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  3. Chunsheng Kang
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  4. Peiyu Pu
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  5. Zhen Fu
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Correspondence to Yongping You .

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    M.A. Hayat

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You, Y., Liu, N., Kang, C., Pu, P., Fu, Z. (2012). Role of MicroRNA in Glioma. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 4. Tumors of the Central Nervous System, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1706-0_9

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  • DOI: https://doi.org/10.1007/978-94-007-1706-0_9

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