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Desmoid Tumors pp 17–28Cite as

Pathology of Desmoid Tumors

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Abstract

Desmoid fibromatosis is an uncommon locally aggressive fibroblastic/myofibroblastic neoplasm with no metastatic ability. The pathologic diagnosis is usually straightforward but can be difficult in small biopsies and in recurrences associated with scars from a prior procedure. Immunohistochemistry, specifically β-catenin, and more recently, molecular diagnostics can play an important role in its diagnosis. This chapter reviews the clinical and pathological features, highlights the role of immunohistochemistry and molecular studies in distinguishing desmoids from potential mimics, and briefly discusses the clinical behavior with reference to possible predictors of recurrence.

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Authors and Affiliations

  1. Department of Pathology, MD Anderson Cancer Center, University of Texas, 77030, Houston, Texas, USA

    Wai Chin Foo

  2. Department of Pathology, Sarcoma Research Center, MD Anderson Cancer Center, University of Texas, 77030, Houston, TX, USA

    Alexander J. Lazar

Authors
  1. Wai Chin Foo
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  2. Alexander J. Lazar
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Corresponding author

Correspondence to Wai Chin Foo .

Editor information

Editors and Affiliations

  1. , Department of Neurology, Columbia University, Summer Street 1290, Stamford, 06905, Connecticut, USA

    Charisse Litchman

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© 2012 Springer Science+Business Media B.V.

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Foo, W., Lazar, A.J. (2012). Pathology of Desmoid Tumors. In: Litchman, C. (eds) Desmoid Tumors. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1685-8_3

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  • DOI: https://doi.org/10.1007/978-94-007-1685-8_3

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-1684-1

  • Online ISBN: 978-94-007-1685-8

  • eBook Packages: MedicineMedicine (R0)

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