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Cell Lines, Tissue Samples, Model Organisms, and Biobanks: Infrastructure and Tools for Cancer Systems Biology

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Cancer Systems Biology, Bioinformatics and Medicine

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Abstract

Despite significant advances in the understanding of cancer , we have seen hitherto only limited translation into improvements in diagnosis and treatment of patients. Further advances in targeted therapies are dependent on well-characterized cell line s for drug evaluation and testing as a preclinical entry point into the pharmaceutical development pipeline. Model organism systems to investigate cancer as a living, breathing organism functioning in three-dimensional space will increase in importance for testing novel therapeutics. Cell lines and xenograft systems have significant limitations. High-quality annotated banked tumour tissue is of fundamental importance for the investigation of cancer biomarkers , molecular pathways , and networks. These components are key parts of systems biology strategies for understanding and individualizing the treatment of human cancer .

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  1. Department of Thoracic Surgery, University Hospital, Raemistr. 101, 8091, Zurich, Switzerland

    Dr. Sandra Tomaszek MD & Dr. Dennis S. Tomaszek MD PhD

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  2. Dr. Dennis S. Tomaszek MD PhD
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Correspondence to Dennis S. Tomaszek MD PhD .

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  1. Via vi Valcannuta 247, Rome, 00166, Italy

    Alfredo Cesario

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    Frederick Marcus

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Tomaszek, S., Tomaszek, D.S. (2011). Cell Lines, Tissue Samples, Model Organisms, and Biobanks: Infrastructure and Tools for Cancer Systems Biology. In: Cesario, A., Marcus, F. (eds) Cancer Systems Biology, Bioinformatics and Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1567-7_4

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