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Methods for the Preparation of Optically Active Chiral Compounds

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Green Approaches To Asymmetric Catalytic Synthesis

Part of the book series: SpringerBriefs in Molecular Science ((GREENCHEMIST,volume 4))

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Abstract

The biological activity of chiral compounds is markedly affected by their chirality and there is a growing demand for the synthesis of such molecules in enantiopure form in order to limit and/or suppress adverse effects deriving from the use of the racemic mixtures. This tendency is in agreement with the objectives of “green chemistry”, that gives a central emphasis to the protection of human and environmental health through the design of new chemicals and processes. Among the different methods for the preparation of optically active compounds, racemic resolutions can be improved by addition of racemization step to recycle the unwanted enantiomer or by using automated chromatographic methodologies. In stoichiometric asymmetric synthesis the use of chiral substrates or auxiliary groups allows to control the stereochemical outcome of several reactions through intramolecular transfer of chirality. Although these methodologies continue to be widely employed, asymmetric catalysis has emerged as more sustainable option and some processes have been yet applied at industrial level.

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  1. National Research Council of Italy, Institute of Biomolecular Chemistry, Via Paolo Gaifami 18, 95126, Catania, Italy

    Angela Patti

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© 2011 Angela Patti

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Patti, A. (2011). Methods for the Preparation of Optically Active Chiral Compounds. In: Green Approaches To Asymmetric Catalytic Synthesis. SpringerBriefs in Molecular Science(), vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1454-0_1

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