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Black–White Divergence Influencing Impaired Fasting Glucose and Type 2 Diabetes Mellitus

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Abstract

Impaired glucose homeostasis is one of the most common causes of death in the U.S. The progressive global epidemic of obesity makes it a major causal factor for pre-diabetes and type 2 diabetes, which may represent the two categories of impaired glucose regulation. Recognition of the importance of black–white contrast in the prevalence of type 2 diabetes mellitus has stirred up interest in its potential role in the development and progression of diabetes. Accumulating evidence suggests that multiple cardiometabolic risk factors such as insulin resistance/hyperinsulinemia, adiposity, genetic predisposition, low birth weight, prepuberty, inflammation markers including C-reactive protein and adiponectin, chronic kidney dysfunction, and environmental and socio-economic status lead to the black–white divergence in type 2 diabetes. Early prevention and intervention for these risk factors, especially obesity and altered lifestyles involving physical activity and dietary consumption, may help to neutralize the racial disparities seen in the emerging epidemic of diabetes beginning in youth.

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Authors and Affiliations

  1. Center for Cardiovascular Health, Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA

    Quoc Manh Nguyen

  2. Center for Cardiovascular Health, Department of Epidemiology, Biochemistry, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA

    Sathanur R. Srinivasan

  3. Center for Cardiovascular Health, Department of Medicine, Pediatrics, Biochemistry, Epidemiology, Tulane University School of Medicine and School of Public Health and Tropical Medicine, New Orleans, LA, USA

    Gerald S. Berenson

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  1. Quoc Manh Nguyen
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  2. Sathanur R. Srinivasan
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  3. Gerald S. Berenson
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Correspondence to Quoc Manh Nguyen .

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  1. , Department of Epidemiology, Tulane University, Canal Street 1440, New Orleans, 70112, Louisiana, USA

    Gerald S. Berenson

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Nguyen, Q., Srinivasan, S.R., Berenson, G.S. (2011). Black–White Divergence Influencing Impaired Fasting Glucose and Type 2 Diabetes Mellitus. In: Berenson, G. (eds) Evolution of Cardio-Metabolic Risk from Birth to Middle Age:. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1451-9_5

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