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The Cardiovascular Risk in Young Finns Study and the Special Turku Coronary Risk Factor Intervention Project (STRIP)

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Evolution of Cardio-Metabolic Risk from Birth to Middle Age:

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Abstract

In the longitudinal Young Finns study, cardiovascular risk factors were first assessed in 1980 in 3,596 children aged 3–18 years. The latest follow-up examinations were performed in 2001 and 2007, when risk factors and early markers of atherosclerosis in carotid and brachial arteries were examined among 2,653 subjects from the original cohorts, now aged 24–45 years. The results show that an individual’s risk factor profile is regulated by early lifestyle-related factors and that exposure to risk factors in childhood induces changes in arteries that contribute to the development of atherosclerosis in adulthood. In the STRIP study, 1,062 infants were randomized into an intervention group (n = 540; low-saturated-fat, low-cholesterol diet) or a control group (n = 522) at 7 mo of age in 1989. STRIP has demonstrated the benefits, e.g. improved lipid levels and brachial endothelial function, of low-saturated-fat diet that could be initiated at an early age. In addition, active exercise habits and non-smoking should be encouraged since they influence vascular endothelial function in childhood. No stronger justification for aiming at improvement of CVD risk factor levels, including serum cholesterol values, blood pressure and obesity, can be provided.

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Authors and Affiliations

  1. Department of Pediatrics, Research Center of Applied and Preventive Cardiovascular Medicine, Medicine and Clinical Physiology, University of Turku and Turku University Hospital, Turku, Finland

    Markus Juonala, Costan G. Magnussen, Olli Simell, Harri Niinikoski, Olli T. Raitakari & Jorma S. A. Viikari

  2. Murdoch Childrens Research Institute Melborne, Melborne, Australia

    Costan G. Magnussen

Authors
  1. Markus Juonala
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  2. Costan G. Magnussen
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  3. Olli Simell
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  4. Harri Niinikoski
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  5. Olli T. Raitakari
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  6. Jorma S. A. Viikari
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Correspondence to Markus Juonala .

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Editors and Affiliations

  1. , Department of Epidemiology, Tulane University, Canal Street 1440, New Orleans, 70112, Louisiana, USA

    Gerald S. Berenson

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Juonala, M., Magnussen, C.G., Simell, O., Niinikoski, H., Raitakari, O.T., Viikari, J.S. (2011). The Cardiovascular Risk in Young Finns Study and the Special Turku Coronary Risk Factor Intervention Project (STRIP). In: Berenson, G. (eds) Evolution of Cardio-Metabolic Risk from Birth to Middle Age:. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1451-9_10

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