Abstract
Inflammatory myofibroblastic tumors (IMT) are rare tumors of unknown etiology, composed of proliferating myofibroblasts and accompanying lymphoplasmacytic infiltration. They are most commonly seen in the lung, but may rarely occur in other organs. The authors review the current literature of coexisting inflammatory myofibroblastic tumors of lung and brain.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Arber DA, Weiss LM, Chang KL (1998) Detection of Ebstein-Barr virus in inflammatory pseudotumor. Semin Diagn Pathol 15:155–160
Bahadori M, Liebow AA (1973) Plasma cell granulomas of the lung. Cancer 31:191–208
Brunn H (1939) Two interesting benign lung tumors of contradictory histopathology: remarks on the necessity of maintaining chest tumor registry. J Thorac Surg 9:119–131
Chan YF, White J, Brash H (1994) Metachronous pulmonary and cerebral inflammatory pseudotumor in a child. Pediatr Pathol 14:805–815
Chetty R, Govender D (1997) Inflammatory pseudotumor of the breast. Pathology 29:270–271
Clarke AJ, Jacques TS, Galloway MJ, Thom M, Kitchen ND, Plant GT (2005) ALK positive inflammatory myofibroblastic tumour of the pineal region. J Clin Pathol 58:981–983
Coffin CM, Humphrey PA, Dehner LP (1998) Extrapulmonary inflammatory myofibroblastic tumor: a clinical and pathological survey. Semin Diagn Pathol 15:85–101
Coffin CM, Watterson J, Priest JR, Dehner LP (1995) Extrapulmonary inflammatory myofibroblastic tumor: a clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 19:859–872
Dagash H, Koh C, Cohen M, Sprigg A, Walker J (2009) Inflammatory myofibroblastic tumor of the pancreas: a case report of 2 pediatric cases–steroids or surgery? J Pediatr Surg 44:1839–1841
Dogra VS, Bhatt S (2009) Inflammatory pseudotumor of the kidney. Ultrasound Q 25:69–70
Fletcher CD (1998) Myofibroblastic tumors: an update. Verh Dtsch Ges Pathol 82:75–82
Germanidis G, Xanthakis I, Tsitouridis I, Zaramboukas T, Kiskinis D, Konstantaras C, Miliaras S, Sirakos T, Pagkalos E (2005) Regression of myofibroblastic tumor of the gastrointestinal tract under infliximab treatment. Dig Dis Sci 2:262–265
Gomez-Roman JJ, Ocejo-Vinyals G, Sánchez-Velasco P, Nieto EH, Leyva-Cobián F, Val-Bernal JF (2000) Presence of human herpesvirus-8 DNA sequences and overexpression of human IL-6 and cyclin D1 in inflammatory myofibroblastic tumor. Lab Invest 80:1121–1126
Govender D, Chetty R (1997) Inflammatory pseudotumor and Rosai-Dorfman disease of soft tissue: a histological continuum? J Clin Pathol 50:79–81
Greiner C, Rickert CH, Möllman FT, Rieger B, Semik M, Heindel W, Wassmann H (2003) Plasma cell granuloma involving lung and brain. Acta Neurochir 145:1127–1131
Griffin CA, Hawkins AL, Dvorak C, Henkle C, Ellingham T, Perlman EJ (1999) Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. Cancer Res 59:2776–2780
Hagenstad CT, Kilpatrick SE, Pettenati MJ, Savage PD (2003) Inflammatory myofibroblastic tumor with bone marrow involvement. A case report and review of the literature. Arch Pathol Lab Med 127:865–867
Hartyánszky IL, Kádár K, Hubay M (2000) Rapid recurrence of an inflammatory myofibroblastic tumor in the right ventricular outflow tract. Cardiol Young 10:271–274
Herman TE, Shackelford GD, Ternberg JL, Dehner LP (1994) Inflammatory myofibroblastic tumor of the spleen: report of a case in an adolescent. Pediatr Radiol 24:280–282
Horneff G, Jürgens H, Hort W, Karitzky D, Göbel U (1996) Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): response to methotrexate and mercaptopurine. Med Pediatr Oncol 27:187–192
Jeba J, John S, Backiyanathan S, Christopher DJ, Kurian S (2008) Inflammatory pseudotumour of the lung with sarcomatous brain metastasis. Eur J Cancer Care 17:412–414
Karnak I, Senocak ME, Ciftci AO, Cağlar M, Bingöl-Koloğlu M, Tanyel FC, Büyükpamukçu N (2001) Inflammatory myofibroblastic tumor in children: diagnosis and treatment. J Pediatr Surg 36:908–912
Kim JH, Cho JH, Park MS, Chung JH, Lee JG, Kim YS, Kim SK, Shin DH, Choi BW, Choe KO, Chang J (2002) Pulmonary inflammatory pseudotumor – a report of 28 cases. Korean J Intern Med 17:252–258
Koirala R, Shakya VC, Agrawal CS, Khaniya S, Pandey SR, Adhikary S, Pathania OP (2010) Retroperitoneal inflammatory myofibroblastic tumor. Am J Surg 199:e17–e19
Kojima M, Suzuki M, Shimizu K, Masawa N (2009) Inflammatory pseudotumor of the thyroid gland showing prominent fibrohistiocytic proliferation. A case report. Endocr Pathol 20:186–190
Lawson SL, Azoumah DK, Lawson-Evi K, N’Timon B, Savi de Tove HM, Yehouessi-Vignikin B, Kpemissi E (2010) Inflammatory myofibroblastic tumour of nose and paranasal sinuses in a little girl of 7-year-old. Arch Pediatr 17:34–37
Le Marc’hadour F, Lavielle JP, Guilcher C, Brambilla E, Brichon PY, Lebas JF, Charachon R, Pasquier B (1995) Coexistence of plasma cell granulomas of lung and central nervous system. Pathol Res Pract 191:1038–1045
Makino K, Murukami M, Kitano Y, Ushio Y (1995) Primary intracranial plasma-cell granuloma. A case report and review of the literature. Surg Neurol 43:374–378
Malhotra V, Tatke M, Malik R, Gondal R, Beohar PC, Kumar S, Puri V (1991) An unusual case of Plasma cell granuloma involving lung and brain. Ind J Cancer 28:223–227
Matsubara O, Tan-Liu NS, Kenney RM, Mark EJ (1988) Inflammatory pseudotumors of the lung: progression from organizing pneumonia to fibrous histiocytoma or to plasma cell granuloma in 32 cases. Hum Pathol 19:807–814
Narla LD, Newman B, Spottswood SS, Narla S, Kolli R (2003) Inflammatory pseudotumor. Radiographics 3:719–729
Petridis AK, Hempelmann RG, Hugo HH, Eichmann T, Mehdorn HM (2004) Metastatic low-grade inflammatory myofibroblastic tumor in the central nervous system of a 29-year old male patient. Clin Neuropathol 23:158–166
Rabban JT, Zaloudek CJ, Shekitka KM, Tavassoli FA (2005) Inflammatory myofibroblastic tumor of the uterus: a clinicopathologic study of 6 cases emphasizing distinction from aggressive mesenchymal tumors. Surg Pathol 29:1348–1355
Sanders BM, West KW, Gingalewski C, Engum S, Davis M, Grosfeld JL (2001) Inflammatory pseudotumor of the alimentary tract: clinical and surgical experience. J Pediatr Surg 36:169–173
Scott L, Blair G, Taylor G, Dimmick J, Fraser G (1988) Inflammatory pseudotumors in children. J Pediatr Surg 23:755–758
Shah MD, McClain KL (2005) Intracranial plasma cell granuloma: case report and treatment of recurrence with methotrexate and 6-mercaptopurine. J Pediatr Hematol Oncol 27:599–603
Sharma S, Sankhyan N, Kalra V, Garg A, Gupta SD, Agarwala S, Das P (2009) Inflammatory myofibroblastic tumor involving lung and brain in a 10-year-old boy: a case report. J Child Neurol 24:1302–1306
Su LD, Atayde-Perez A, Sheldon S, Fletcher JA, Weiss SW (1998) Inflammatory myofibroblastic tumor: cytogenetic evidence supporting clonal origin. Mod Pathol 11:364–368
Su W, Ko A, O’Connell TX, Applebaum H (2000) Treatment of pseudotumors with nonsteroidal anti-inflammatory drugs. J Pediatr Surg 35:1635–1637
Sugiyama K, Nakajima Y (2008) Inflammatory myofibroblastic tumor in the mediastinum mimicking a malignant tumor. Diagn Interv Radiol 14:197–199
Swain RS, Tihan T, Horvai AE, Di Vizio D, Loda M, Burger PC, Scheithauer BW, Kim GE (2008) Inflammatory myofibroblastic tumor of the central nervous system and its relationship to inflammatory pseudotumor. Hum Pathol 39:410–419
Tang L, Lai EC, Cong WM, Li AJ, Fu SY, Pan ZY, Zhou WP, Lau WY, Wu MC (2010) Inflammatory myofibroblastic tumor of the liver: a cohort study. World J Surg 34:309–313
Tang TT, Segura AD, Oechler HW, Harb JM, Adair SE, Gregg DC, Camitta BM, Franciosi RA (1990) Inflammatory myofibrohistiocytic proliferation simulating sarcoma in children. Cancer 65:1626–1634
Tavora F, Shilo K, Ozbudak IH, Przybocki JM, Wang G, Travis WD, Frank TJ (2007) Absence of human herpesvirus-8 in pulmonary inflammatory myofibroblastic tumor: immunohistochemical and molecular analysis of 20 cases. Mod Pathol 20:995–999
Tekkök IH, Ventureyra EC, Jimenez CL (2000) Intracranial plasma cell granuloma. Brain Tumor Pathol 17:97–103
Trojan A, Stallmach T, Kollias S, Pestalozzi BC (2001) Inflammatory myofibroblastic tumor with CNS involvement. Onkologie 24:368–372
Vadmal MS, Pellegrini AE (1999) Inflammatory myofibroblastic tumor of the skin. Am J Dermatopathol 21:449–453
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media B.V.
About this chapter
Cite this chapter
Sankhyan, N., Sharma, S., Gulati, S. (2011). Coexsistence of Inflammatory Myofibroblastic Tumor in the Lung and Brain. In: Hayat, M. (eds) Tumors of the Central Nervous system, Volume 3. Tumors of the Central Nervous System, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1399-4_7
Download citation
DOI: https://doi.org/10.1007/978-94-007-1399-4_7
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-1398-7
Online ISBN: 978-94-007-1399-4
eBook Packages: MedicineMedicine (R0)