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Brain Tumors: Convection-Enhanced Delivery of Drugs (Method)

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Tumors of the Central Nervous system, Volume 3

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 3))

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Abstract

Delivery of therapeutic agents into the brain has been an ongoing challenge for many years. The poor prognosis for patient with primary malignant brain tumors treated with conventional techniques (surgery, radiotherapy and chemotherapy) has motivated the development of new strategies to deliver drugs into the brain. Local intracranial delivery of antineoplastic agents has appeared to be the most effective drug delivery technique into the central nervous system by circumventing the limitations imposed by the blood brain barrier (BBB). Convection-enhanced delivery (CED) is an alternative strategy to directly infuse drugs into brain tissue. This approach is based on continuous injection of the therapeutic agent under positive pressure via a catheter implanted into the brain. Convective transport driven by pressure gradient allows a widespread distribution of small and large drugs within the brain. In vivo experiments in rodents, cats and primates proved the efficacy of CED to deliver drugs into a targeted zone. However, clinical trials have reported frequent leakage phenomenon leading to mixed results for this delivery technique. A better optimization of operational parameters including infusion rate, catheter design, catheter placement and drug pharmacological formulation should allow achieving accurate and efficient delivery. In conjunction with CED, the use of nanocarriers to enhance drug pharmacokinetic behavior may help to achieve higher therapeutic index against tumor cells over healthy tissues. Additionally, the development of computer simulation to predict drug distribution and the real-time imaging for immediate assessment of convection efficiency may contribute to the CED improvement.

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Authors and Affiliations

  1. INSERM, U646, Universite d’Angers, Angers, F-491000, France

    Anne-Laure Laine, Emilie Allard, Philippe Menei & Catherine Passirani

  2. Centre Hospitalier Universitaire d’Angers, Angers cedex 9, F-49933, France

    Philippe Menei

Authors
  1. Anne-Laure Laine
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  2. Emilie Allard
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  3. Philippe Menei
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  4. Catherine Passirani
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Corresponding author

Correspondence to Catherine Passirani .

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Editors and Affiliations

  1. , Kean University, Department of Biological Sciences, Morris Avenue 1000, UNION, 07083, New Jersey, USA

    M.A. Hayat

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Laine, AL., Allard, E., Menei, P., Passirani, C. (2011). Brain Tumors: Convection-Enhanced Delivery of Drugs (Method). In: Hayat, M. (eds) Tumors of the Central Nervous system, Volume 3. Tumors of the Central Nervous System, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1399-4_21

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  • DOI: https://doi.org/10.1007/978-94-007-1399-4_21

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  • Publisher Name: Springer, Dordrecht

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  • Online ISBN: 978-94-007-1399-4

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