Skip to main content
SpringerLink
Log in

Malignant Peripheral Nerve Sheath Tumors: Use of 18FDG-PET/CT

  • Chapter
  • First Online:
Tumors of the Central Nervous system, Volume 3

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 3))

  • 1673 Accesses

Abstract

Malignant Peripheral Nerve Sheath Tumors (MPNST) are rare but lethal lesions. They are more often found in patients with the cancer pre-disposition syndrome, Neurofibromatosis 1 (NF1). NF1 patients harbor many peripheral nerve tumors, the majority of which are benign. Early detection of these benign plexiform neurofibromas (PNf), which may have transformed to a MPNST, is of paramount importance in the long term management and outcome of these patients. However, surveillance of these PNfs is cumbersome as the clinical and radiological features suggestive of malignant transformation are often inaccurate and surgery can lead to significant morbidity. One imaging strategy that is of promise is to take advantage of the fact that malignant tumors inherently are actively proliferating with accompanying increased and altered glucose metabolism, compared to benign lesions. This is the theoretical premise for using 18-Fluorodeoxyglucose (18-FDG)-Positron Emission Tomography (PET) imaging to help diagnose and guide management of MPNSTs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Anghileri M (2006) Malignant peripheral nerve sheath tumors – prognostic factors and survival in a series of patients treated at a single institution. Cancer 107:1065–1074

    Article  PubMed  Google Scholar 

  • Antoch G, Saoudi N, Kuehl H, Dahmen G, Mueller SP, Beyer T, Bockisch A, Debatin JF, Freudenberg LS (2004) Accuracy of whole body dual-modality fluorine-18-2-fluoro-2-D-glucose positron emission tomography and computed tomography (FDG-PET/CT) for tumor staging in solid tumors: comparison with CT and PET. J Clin Oncol 22:4357– 4368

    Article  PubMed  Google Scholar 

  • Benz MR, Czernin J, Dry SM, Tap WD, Allen-Auerbach MS, Elashoff D, Phelps ME, Weber WA, Eiber F (2010) Quantitative F18-fluorodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign. Cancer 116:451–458

    Article  PubMed  CAS  Google Scholar 

  • Beyer T, Townsend DW, Brun T, Kinahan PE, Charron M, Roddy R, Jerin J, Young J, Byars L, Nutt R (2000) A combined PET/CT scanner for clinical oncology. J Nucl Med 41(8):1369–1379

    PubMed  CAS  Google Scholar 

  • Birindelli A, Perrone F, Oggionni M, Lavarino C, Pasini B, Vergani B, Ranzani GN, Pierotti MA, Pilotti S (2001) Pathway alterations in sporadic and NF1-related malignant peripheral nerve sheath tumours. Lab Invest 81:833–844

    PubMed  CAS  Google Scholar 

  • Cardona S, Schwarzbach M, Hinz U, Dimitrakopoulou-Strauss A, Attigah N, Mechtersheimer G, Lehnert T (2003) Evaluation of F18-deoxyglucose positron emission tomography (FDG PET) to assess the nature of neurogenic tumours. Eur J Surg Oncol (EJSO) 29:536–541

    Article  CAS  Google Scholar 

  • D’Agostino AN, Soule EH, Miller RH (1963) Sarcomas of the peripheral nerves and somatic soft tissue associated with multiple neurofibromatosis (von Recklinghausen’s disease). Cancer 16:1015–1027

    Article  PubMed  Google Scholar 

  • De Raedt T, Brems H, Wolkenstein P, Vidaud D, Pilotti S, Perrone F, Mautner V, Frahm S, Sciot R, Legius E (2003) Elevated risk for MPNST in NF1 microdeletion patients. Am J Hum Genet 72:1288–1292

    Article  PubMed  Google Scholar 

  • Doorn PF, Molenaar WM, Buter J, Hoekstra HJ (1995) Malignant peripheral nerve sheath tumors in patients with and without neurofibromatosis. Eur J Surg Oncol 21:78–82

    Article  PubMed  CAS  Google Scholar 

  • Ducatman BS, Scheithauer BW, Piepgras DG (1986) Malignant peripheral nerve sheath tumors: a clinicopathologic study 120 cases. Cancer 57:2006–2021

    Article  PubMed  CAS  Google Scholar 

  • Ferner RE, Lucas JD, O’Doherty MJ, Hughes RA, Smith MA, Cronin BF, Bingham J (2000) Evaluation of (18) fluorodeoxyglucose positron emission tomography (18 FDG PET) in the detection of malignant peripheral nerve sheath tumors arising from within plexiform neurofibromas in neurofibromatosis 1. J Neurol Neurosurg Psychiatry 68:353–357

    Article  PubMed  CAS  Google Scholar 

  • Frank D, Gunawan B, Holtrup M, Füzesi L (2003) Cytogenetic characterization of three malignant peripheral nerve sheath tumors. Cancer Genet Cytogen 144:18–22

    Article  CAS  Google Scholar 

  • Grobmyer SR, Reith JD, Shahlaee A, Bush CH, Hochwald SN (2008) Malignant peripheral nerve sheath tumor: molecular pathogenesis and current management considerations. J Surg Oncol 97:340–349

    Article  PubMed  CAS  Google Scholar 

  • Hruban RH, Shiu MH, Senie RT (1990) Malignant peripheral nerve sheath tumors of the buttock and lower extremity: a study of 43 cases. Cancer 66:1253–1265

    Article  PubMed  CAS  Google Scholar 

  • Iagaru A, Quon A, McDougall IR, Gambhir SS (2006) F-18 FDG PET/CT evaluation of osseous and soft tissue sarcomas. Clin Nucl Med 31:754–760

    Article  PubMed  Google Scholar 

  • Karabatsou K, Kiehl T-R, Wilson DM, Hendler A, Guha A (2009) Potential role of 18 fluorodeoxyglucose positron emission tomography/computed tomography in differentiating benign neurofibroma from malignant peripheral nerve sheath tumor associated with Neurofibromatosis 1. Neurosurgery 65:A160–A170

    Article  PubMed  Google Scholar 

  • King AA, DeBaun MR, Riccardi VM, Gutmann DH (2000) Malignant peripheral nerve sheath tumors in Neurofibromatosis 1. Am J Med Gene 93:388–392

    Article  CAS  Google Scholar 

  • Ozturk E, Erdem I, Sonmez G, Haholu A, Sildiroglu HO, Mutlu H, Basekim CC, Kizilkaya E (2007) Multicentric malignant peripheral nerve sheath tumor. Clin Imaging 31:363–366

    Article  PubMed  Google Scholar 

  • Perrone F, Tabano S, Colombo F, Dagrada G, Birindelli S, Gronchi A, Colecchia M, Pierotti MA, Pilotti S (2003) p15INK4b, p14ARF and p16INK4a inactivation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumours. Clin Cancer Res 9:4132–4138

    PubMed  CAS  Google Scholar 

  • Plaat BE, Molenaar WM, Mastik MF, Hoekstra HJ, te Meerman GJ, van den Berg E (1999) Computer assisted cytogenetic analysis of 51 malignant peripheral nerve sheath tumors: sporadic vs. neurofibromatosis type 1 associated malignant schwannomas. Int J Cancer 83:171–178

    Article  PubMed  CAS  Google Scholar 

  • Ratner N, Miller SJ (2006) Model systems for neurofibroma and malignant nerve sheath tumor drug discovery today: disease models. Cancer 3(2):175–182

    Google Scholar 

  • Schmidt H, Würl P, Taubert H, Meye A, Bache M, Holzhausen H-J, Hinze R (1999) Genomic imbalances of 7p and 17 q in malignant peripheral nerve sheath tumors are clinically relevant. Gene Chromos Cancer 25:205–211

    Article  CAS  Google Scholar 

  • Shintani K, Matsumine A, Kusuzaki K (2006) Expression of hypoxia inducible factor (HIF) 1-alpha as a biomarker of outcome in soft tissue sarcomas. Virch Arch 449:673–681

    Article  CAS  Google Scholar 

  • Sordillo PP, Helson L, Hajdu SI (1981) Malignant schwannoma – clinical characteristics, survival and response to therapy. Cancer 47:2503–2509

    Article  PubMed  CAS  Google Scholar 

  • Sorensen SA, Mulvihill JJ, Nielsen A (1986) Long-term follow up of von Recklinghausen neurofibromatosis. N Engl J Med 314:1010–1015

    Article  PubMed  CAS  Google Scholar 

  • Wong WW, Hirose T, Scheithauer BW, Schild SE, Gunderson LL (1998) Malignant peripheral nerve sheath tumor: analysis of treatment and outcome. Int J Rad Oncol Biol Phys 42(2):351–360

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Neurosurgery, Toronto Western Hospital, Toronto, ON, Canada

    Andre A. le Roux & Abhijit Guha

Authors
  1. Andre A. le Roux
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Abhijit Guha
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Abhijit Guha .

Editor information

Editors and Affiliations

  1. , Kean University, Department of Biological Sciences, Morris Avenue 1000, UNION, 07083, New Jersey, USA

    M.A. Hayat

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

le Roux, A.A., Guha, A. (2011). Malignant Peripheral Nerve Sheath Tumors: Use of 18FDG-PET/CT. In: Hayat, M. (eds) Tumors of the Central Nervous system, Volume 3. Tumors of the Central Nervous System, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1399-4_13

Download citation

  • DOI: https://doi.org/10.1007/978-94-007-1399-4_13

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-1398-7

  • Online ISBN: 978-94-007-1399-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation