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Advances on Modeling in Tissue Engineering pp 137–176Cite as

Biofabrication Strategies for Tissue Engineering

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Part of the book series: Computational Methods in Applied Sciences ((COMPUTMETHODS,volume 20))

Abstract

The success of Tissue Engineering (TE) strongly relies on the capability of designing biomimetic scaffolds closely resembling the host tissue environment. Due to the functional multitude of the native tissues, the considerations are complex and include chemical, morphological, mechanical and biological factors and their mutability with time. Nonetheless, to trigger and/or assist the “natural healing mechanism’’ of the human body it seems essential to provide an appropriate biomechanical environment and biomolecular signalling to the cells. Novel biomanufacturing processes are increasingly being recognized as ideal techniques to produce 3D biodegradable structures with optimal pore size and spatial distribution, providing an adequate mechanical support for tissue regeneration while shaping in-growing tissues. In this chapter, we discuss in detail the most recent advances in the field of biofabrication, providing and updated overview of processes and materials employed in the production of tissue engineering constructs. Bioprinting or ‘’scaffold-less’’ strategies are also presented in this work. They are based on the precise deposition of high-density tissue spheroids or cell aggregates being advantageous alternatives to the current scaffold-based tissue engineering approach.

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Authors and Affiliations

  1. Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, Centro Empresarial da Marinha Grande, Rua de Portugal, 2430-028, Marinha Grande, Portugal

    Paulo Jorge Bártolo, Marco Domingos & Tatiana Patrício

  2. Department of Chemistry & Industrial Chemistry, University of Pisa, 56126, Pisa, Italy

    Stefania Cometa

  3. Advanced Tissue Biofabrication Center, Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina Charleston, Charleston, SC, 29425, USA

    Vladimir Mironov

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  1. Paulo Jorge Bártolo
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  2. Marco Domingos
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  3. Tatiana Patrício
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  4. Stefania Cometa
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  5. Vladimir Mironov
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Correspondence to Paulo Jorge Bártolo .

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  1. IDMEC – Instituto de Engenharia Mecânica, Instituto Superior Técnico, Av. Rovisco Pais 1, Lisboa, 1049-001, Portugal

    Paulo R. Fernandes

  2. Polytechnic Institute of Leiria, Centre for Rapid and Sustainable Product, Leiria, Portugal

    Paulo Jorge Bártolo

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Bártolo, P.J., Domingos, M., Patrício, T., Cometa, S., Mironov, V. (2011). Biofabrication Strategies for Tissue Engineering. In: Fernandes, P., Bártolo, P. (eds) Advances on Modeling in Tissue Engineering. Computational Methods in Applied Sciences, vol 20. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1254-6_8

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