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Modelling bone tissue engineering. Towards an understanding of the role of scaffold design parameters

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Advances on Modeling in Tissue Engineering

Part of the book series: Computational Methods in Applied Sciences ((COMPUTMETHODS,volume 20))

Abstract

Tissue engineering emerged in the beginning of 90’s as a new paradigm in medicine and life sciences. A number of successful results have been reported although the clinical practice has not been reached so far. One of the problems encountered in this methodology is the coordination among the different biophysical fields involved and the uncertain behaviour of a specific cell carrier, i.e, scaffolds in each application. Moreover, the role of the scaffold design in tissue regeneration is poorly understood and new protocols have to be tested over different tissues. In order to advance in the knowledge of the scaffold behaviour towards its functionality and to reduce animal experimentation, computer simulation may serve as a useful platform for scaffold design, once the models are sufficiently validated. In this framework, the potential of numerical simulation, based on a multiscale and multiphysic approach, is highlighted in this work. Furthermore, the role of scaffold microstructural anisotropy in bone tissue regeneration is analyzed using this approach.

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Author information

Authors and Affiliations

  1. Group of Structural Mechanics and Materials Modeling, Aragón Insitute of Engineering Research (I3A), University of Zaragoza, Seville, Spain

    José A. Sanz-Herrera, Manuel Doblaré & José M. García-Aznar

  2. CIBER-BBN Centro Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina and School of Engineering, University of Seville, Seville, Spain

    José A. Sanz-Herrera

  3. CIBER-BBN Centro Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Seville, Spain

    Manuel Doblaré & José M. García-Aznar

Authors
  1. José A. Sanz-Herrera
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  2. Manuel Doblaré
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  3. José M. García-Aznar
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Corresponding author

Correspondence to José A. Sanz-Herrera .

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Editors and Affiliations

  1. IDMEC – Instituto de Engenharia Mecânica, Instituto Superior Técnico, Av. Rovisco Pais 1, Lisboa, 1049-001, Portugal

    Paulo R. Fernandes

  2. Polytechnic Institute of Leiria, Centre for Rapid and Sustainable Product, Leiria, Portugal

    Paulo Jorge Bártolo

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Sanz-Herrera, J.A., Doblaré, M., García-Aznar, J.M. (2011). Modelling bone tissue engineering. Towards an understanding of the role of scaffold design parameters. In: Fernandes, P., Bártolo, P. (eds) Advances on Modeling in Tissue Engineering. Computational Methods in Applied Sciences, vol 20. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1254-6_5

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  • DOI: https://doi.org/10.1007/978-94-007-1254-6_5

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-1253-9

  • Online ISBN: 978-94-007-1254-6

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