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Calcium Phosphate and Calcium Phosphosilicate Mediated Drug Delivery and Imaging

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Intracellular Delivery

Part of the book series: Fundamental Biomedical Technologies ((FBMT,volume 5))

Abstract

Nanotechnology-based imaging, drug and gene delivery systems can be used to improve current diagnostic and therapeutic approaches. Calcium phosphate (CP) and calcium phosphosilicate (CPS) based nanoparticulate systems are becoming increasingly popular as delivery vehicles for therapeutic and imaging agents due to biocompatible and biodegradable properties of the material. In this chapter, we emphasize properties of the various calcium phosphates that make these materials promising nanocarriers and we provide an overview of the architectures of different calcium phosphate systems including the nanocomposite calcium phosphosilicate nanoparticles, hybrid CP-liposome and CP-polymeric systems. The versatility of calcium phosphate based delivery systems for therapeutic and imaging applications is emphasized.

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Abbreviations

7-OH-DPAT:

7-hydroxy-2-dipropyl-aminotetralin

AAV:

adeno-associated virus

ADP:

adenosine diphosphate

ATP:

adenosine triphosphate

ACP:

amorphous calcium phosphate

APTES:

aminopropyltriethoxysilane

carboxySNARF-1:

carboxy-seminapthorhodafluor

CD71:

Cluster of Differentiation 71 (an antibody for the transferrin receptor)

CEPA:

carboxyethylphosphoric acid

CER6 :

hexanoyl-ceramide

CER10 :

decanoyl ceramide

CHM:

cholesterol-bearing mannan

CHP:

cholesterol-bearing pullalan

CP:

calcium phosphate

CPS:

calcium phosphosilicate

CPSNPs:

calcium phosphosilicate nanocomposite particles

CPP:

casein phosphopeptides

Cy3:

Cy3 Amidite

DMSO:

dimethyl sulfoxide

DNA:

deoxyribonucleic acid

DOPA:

1,2-dioleoylsn-glycero-3-phosphate

DOTAP:

1, 2-dioleoyl-3-trimethylammonium-propane chloride salt

DPBS:

Dulbecco’s phosphate buffered saline

DSPE-PEG:

1,2-distearoryl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol-2000) ammonium salt

EPC:

L-α-phosphatidylcholine

EPR:

enhanced permeation and retention

FCS:

fluorescence correlation spectroscopy

HA:

hydroxyapatite

ICG:

indocyanine green

LD50:

(median) lethal dose, 50%

LCP:

lipid coated calcium phosphate

LNCP:

lipid-coated nano-calcium-phosphate

MPS:

mononuclear phagocytic system

MTT:

3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

PBS:

phosphate buffered saline

PEG:

polyethylene glycol

RES:

reticuloendothelial system

RNA:

ribonucleic acid

RNAi:

RNA interference

siRNA:

small interfering RNA

ZP:

zeta potential

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Authors and Affiliations

  1. Department of Materials Science and Engineering, Penn State University, University Park, PA, 16802, USA

    O. A. Pinto, A. Tabaković, T. M. Goff, Y. Liu & J. H. Adair

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  1. O. A. Pinto
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  2. A. Tabaković
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  3. T. M. Goff
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  4. Y. Liu
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  5. J. H. Adair
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Correspondence to J. H. Adair .

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  1. , Chemical and Biological Engineering, Vanderbilt University, VU Station B 351604, Nashville, 37235, Tennessee, USA

    Aleš Prokop

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© 2011 Springer Science+Business Media B.V.

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Pinto, O.A., Tabaković, A., Goff, T.M., Liu, Y., Adair, J.H. (2011). Calcium Phosphate and Calcium Phosphosilicate Mediated Drug Delivery and Imaging. In: Prokop, A. (eds) Intracellular Delivery. Fundamental Biomedical Technologies, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1248-5_23

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