Abstract
The term necrosis was used for accidental, not programmed death of cells or tissues with uncontrolled release of cellular content resulting in inflammation. Necrosis is a term used by pathologists to designate the sum of changes that occurred in cell and tissues after they have died. Different experiments carried out in different cell types, species and cell death inducers show several traits that delineate a sequence of intracellular events specific to necrotic cell death. Morphological necrosis is characterized by cellular swelling including dilation of the endoplasmic reticulum, cellular lysis and subsequent inflammation. Core events of necrosis are bioenergetic failure and rapid loss of plasma membrane integrity. These failures results from defined molecular events including increased mitochondrial reactive oxygen species production, channel-mediated calcium uptake, activation of non-apoptotic proteases, swelling of mitochondria, perinuclear clustering of organelles and enzymatic destruction of cofactors required for ATP production, cell lysis and inflammation. The default occurrence of necrosis and its unmasking by inhibition of autophagy and/or apoptosis might reflect its early emergency in evolution.
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Abbreviations
- NAD:
-
Nicotinamide adenine dinucleotide
- ATP:
-
Adenosine triphosphate
- ADP:
-
Adenosine diphosphate
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Vázquez-Nin, G.H., Escobar, M.L., Echeverría, O.M. (2011). Necrosis. In: Cell Death in Mammalian Ovary. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1134-1_7
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DOI: https://doi.org/10.1007/978-94-007-1134-1_7
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