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Apoptosis

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Cell Death in Mammalian Ovary

Abstract

Cell death is a fundamental physiological process involved in controlling the balance between proliferation and differentiation during embryonic development, and in the renewal of cellular tissue throughout adulthood. It is presently known that some alterations in this process modify the cellular behavior and can lead to different pathologies, such as certain cancers and neurodegeneration processes. Apoptosis is the best studied cell death, and it is considered as programmed type I cell death. This process is characterized by several morphological cellular changes where ­cellular shrinkage, chromatin condensation, nuclear fragmentation are included. The apoptosis is executed by a group of proteases, denominated caspases, which lead to the cellular characteristics of the process.

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Abbreviations

APAF1:

Apoptotic protease activating factor 1

Bak:

Bcl-2 antagonist/killer

Bax:

Bcl-2-associated X protein

BH3:

Bcl-2-homology domain-3

Bid:

BH3-interacting-domain

CARD:

Caspases recruitment domain

ced-3:

Caenorhabditis elegans cell-death abnormality-3

DED:

Death effector domain

DISC:

Death-inducing signaling complex

FADD:

Fas associated death domain-containing protein

ICE:

Interleukin-1 converting enzyme

Mcl-1:

Myeloid cell leukemia-1

MOMP:

Mitochondrial outer-membrane permeabilization

PIDD:

p53-Indicible death domain

PUMA:

p53-Upregulated modulator of apoptosis

Smac/DIABLO:

Second mitochondrial activator of caspase/direct IAP-binding protein with low pI

tBID:

Truncated BID

TNFR:

TNF receptor

TNF:

Tumor necrosis factor

TRADD:

TNFR1-associated death domain

TRAIL:

TNF-related apoptosis-inducing ligand

XIAP:

X-linked inhibitor of apoptosis protein

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Authors and Affiliations

  1. Laboratory of Electron Microscopy, Department of Cell Biology, Faculty of Sciences, National University of Mexico (UNAM), Mexico, USA

    María Luisa Escobar, Gerardo H. Vázquez-Nin & Olga M. Echeverría

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  1. María Luisa Escobar
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  2. Gerardo H. Vázquez-Nin
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  3. Olga M. Echeverría
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Correspondence to María Luisa Escobar .

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Escobar, M.L., Vázquez-Nin, G.H., Echeverría, O.M. (2011). Apoptosis. In: Cell Death in Mammalian Ovary. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1134-1_4

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