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References
Bosch J, Abraldes JG, Groszmann R. Current management of portal hypertension. J Hepatol. 2003;38:S54–68.
Garcia-Tsao G. Current management of the complications of cirrhosis and portal hypertension: variceal hemorrhage, ascites, and spontaneous bacterial peritonitis. Gastroenterology. 2001;120:726–48.
Groszmann RJ, Bosch J, Grace ND et al. Hemodynamic events in a prospective randomized trial of propranolol versus placebo in the prevention of a first variceal hemorrhage. Gastroenterology. 1990;99:1401–7.
Feu F, Garcia-Pagan JC, Bosch J et al. Relation between portal pressure response to pharmacotherapy and risk of recurrent variceal haemorrhage in patients with cirrhosis. Lancet. 1995;346:1056–9.
Garcia-Tsao G, Groszmann RJ, Fisher RL, Conn HO, Atterbury CE, Glickman M. Portal pressure, presence of gastroesophageal varices and variceal bleeding. Hepatology. 1985;5:419–24.
Vorobioff J, Groszmann RJ, Picabea E et al. Prognostic value of hepatic venous pressure gradient measurements in alcoholic cirrhosis: a 10-year prospective study. Gastroenterology. 1996;111:701–9.
Villanueva C, Balanzó J, Novella M et al. Nadolol plus isosorbide mononitrate compared with sclerotherapy for the prevention of variceal rebleeding. N Engl J Med. 1996;334:1624–9.
Villanueva C, Minana J, Ortiz J et al. Endoscopic ligation compared with combined treatment with nadolol plus isosorbide mononitrate to prevent recurrent variceal bleeding. N Engl J Med. 2001;345:647–55.
Merkel C, Bolognesi M, Sacerdoti D et al. The hemodynamic response to medical treatment of portal hypertension as a predictor of clinical effectiveness in the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology. 2000;32:930–4.
Abraldes JG, Tarantino I, Turnes J, Garcia-Pagan JC, Rodés J, Bosch J. Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis. Hepatology. 2003;37:902–8.
Villanueva C, López-Balaguer JM, Aracil C et al. Maintenance of hemodynamic response to treatment for portal hypertension and influence on complications of cirrhosis. J Hepatol. 2004;40:757–65.
Boyer TD. Pharmacologic treatment of portal hypertension: past, present and future. Hepatology. 2001;34:834–9.
Kroeger RJ, Groszmann RJ. Increased portal venous resistance hinders portal pressure reduction during the administration of beta-adrenergic blocking agnets in a portal hypertensive model. Hepatology. 1985;5:97–101.
Garcia-Pagan JC, Feu F, Bosch J, Rodés J. Propranolol compared with propranolol plus isosorbide-5-mononitrate for portal hypertension in cirrhosis. A randomized controlled study. Ann Intern Med. 1991;114:869–73.
Merkel C, Sacerdoti D, Bolognesi M et al. Hemodynamic evaluation of the addition of isosorbide-5-mononitrate to nadolol in cirrhotic patients with insufficient response to the b-blocker alone. Hepatology. 1997;26:34–9.
De Franchis R. Updating consensus in portal hypertension: report ofthe Baveno III consensus workshop on definitions, methodology and therapeutic strategies in portal hypertension. J Hepalol. 2000;33:846–52.
Groszmann RJ, Garcia-Tsao G. Endoscopic variceal ligation vs. pharmacological therapy for the prevention of recurrent variceal hemorrhage: What makes the difference? Gastroenterology. 2002;123:1388–91.
D’Amico G, Pagliaro L, Bosch J. Pharmacological treatment of portal hypertension: an evidence-based approach. Semin Liver Dis. 1999;19:475–505.
García-Pagán JC, Villanueva C, Vila MC et al. and Members of the MOVE group. Isosorbide mononitrate in the prevention of first variceal bleed in patients who cannot receive b-blockers. Gastroenterology. 2001;121:908–14.
Garcia-Tsao G, Grace ND, Groszmann RJ et al. Short-term effects of propranolol on portal pressure. Hepatology. 1986;6:101–6.
Vorobioff J, Picabea E, Villavicencio R et al. Acute and chronic hemodynamic effects of propranolol in unselected cirrhotic patients. Hepatology. 1987;7:648–53.
Escorsell A, Bordas JM, Castañeda B et al. Predictive value of variceal pressure response to continued pharmacological therapy in patients with cirrhosis and portal hypertension. Hepatology. 2000;31:1061–7.
Feu F, Bordas JM, Luca A et al. Reduction of variceal pressure by propranolol: comparison of the effects on portal pressure and azygos blood flow in patients with cirrhosis. Hepatology. 1993;18:1082–9.
Garcia-Pagan JC, Navasa M, Bosch J, Bru C, Pizcueta P, Rodés J. Enhancement of portal pressure reduction by the association of isosorbide-5-mononitratc to propranolol administration in patients with cirrhosis. Hepatology. 1990;11:230–8.
Albillos A, García-Pagán JC, Iborra J et al. Propranolol plus prazosin compared with propranolol plus isosorbide-5-mononitrate in the treatment of portal hypertension. Gastroenterology. 1998;115:116–23.
Morillas R, Planas R, Cabré E et al. Propranolol plus isosorbide-5-mononitrate for portal hypertension in cirrhosis: long-term hemodynamic and renal effects. Hepatology. 1994;20:1502–8.
Merkel C, Gatta A, Donada C et al. Long-term effects of nadolol or nadolol plus isosorbide-5-mononitrate on renal function and ascites formation in patients with cirrhosis. Hepatology. 1995;22:808–13.
Gournay J, Masliah C, Martin T, Perrin D, Galmiche JP. Isosorbide mononitrate and propranolol compared with propranolol alone for the prevention of variceal rebleeding. Hepatology. 2000;31:1239–45.
Patti R, D’Amico G, Pasta L et al. Isosorbide mononitrate (IMN) with nadolol compared with nadolol alone for the prevention of recurrent bleeding in cirrhosis. A double-blind placebo-controlled randomized trial. J Hepatol. 1999;30:81 (abstract).
Patch D, Sabin CA, Goulis J et al. A randomized controlled trial of medical therapy versus endoscopic ligation for the prevention of variceal rebleeding in patients with cirrhosis. Gastroenterology. 2002;123:1013–19.
Lo GH, Chen WC, Chen MH et al. Banding ligation versus nadolol and isosorbide mononitrate for the prevention of esophageal variceal bleeding. Gastroenterology. 2002;123:728–34.
McCormick PA, Feu F, Sabrin C, Planas R and the Anglo-Spanish variceal rebleeding group. Propranolol and isosorbide mononitrate versus sclerotherapy or shunt surgery for the prevention of variceal rebleeding: a randomized trial. Hepatology. 1994;20:106A (abstract).
Bureau C, Péron JM, Alric L et al. „A la carte“ treatment of portal hypertension: adapting therapy to hemodynamic response for the prevention of bleeding. Hepatology. 202;36:1361–6.
Thalheimer U, Mela M, Patch D, Burroughs AK. Targeting portal pressure measurements: a critical reappraisal. Hepatology. 2004;39:286–90.
Burroughs AK, D’Heygere F, McIntyre N. Pitfalls in studies of prophylactic therapy for variceal bleeding in cirrhosis. Hepatology. 1986;6:1407–13.
Schneider AW, Kalk JF, Klein CP. Effect of losartan, an angiotensin II receptor antagonist, on portal pressure in cirrhosis. Hepatology. 1999;29:334–9.
Schepke M, Werner E, Bieker E et al. Hemodynamic effects of the angiotensin II receptor antagonist irbesartan in patients with cirrhosis and portal hypertension. Gastroenterology. 2001;121:389–95.
González-Abraldes J, Albillos A, Bañares R et al. Randomized comparison of long-term losartan versus propranolol in lowering portal pressure in cirrhosis. Gastroenterology. 2001;121:382–8.
Debernardi-Venon W, Baronio M, Leone N et al. Effects of irbesartan in reducing portal pressure in cirrhotic patients: comparison with propranolol in a randomised controlled trial. J Hepatol. 2003;38:455–60.
Okumura H, Aramaki T, Katsuta Y et al. Reduction in hepatic venous pressure gradient as a consequence of volume contraction due to chronic administration of spironolactone in patients with cirrhosis and no ascites. Am J Gastroenterol. 1991;86:46–52.
García-Pagán JC, Salmeron JM, Feu F et al. Effects oflow-sodium diet and spironolactone on portal pressure in patients with compensated cirrhosis. Hepatology. 1994;19:1095–9.
Nevens F, Lijnen P, VanBilioen H, Fevery J. The effect of long-term treatment with spironolactone on variceal pressure in patients with portal hypertension without ascites. Hepatology. 1996;23:1047–52.
Abecasis R, Kravetz D, Fassio E et al. Nadolol plus spironolactone in the prophylaxis of first variceal bleed in nonascitic cirrhotic patients: a preliminary study. Hepatology. 2003;37:359–65.
Bañares R, Moitinho E, Piqueras B et al. Carvediol, a new nonselective beta-blocker with intrinsic anti-α-1-adrenergic activity, has greater portal hypotensive effect than propranolol in patients with cirrhosis. Hepatology. 1999;30:79–83.
Bañares R, Moitinho E, Matilla A et al. Randomized comparison of long-term carvedilol and propranolol administration in the treatment of portal hypertension in cirrhosis. Hepatology. 2002;36:1367–73.
Stanley A, Therapondos G, Helmy A, Hayes PC. Acute and chronic haemodynamic and renal effects of carvedilol in patients with cirrhosis. J Hepatol. 1999;30:479–84.
Tripathi D, Therapondos G, Helmy A, Hayes PC. Haemodynamic effects of acute and chronic administration of long-dose carvedilol, a vasodilating beta-blocker, in patients with cirrhosis and portal hypertension. Aliment Pharmacol Ther. 2002;16:373–80.
Wiest R, Gorszmann RJ. The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough. Hepatology. 2002;35:478–91.
Albillos A, Lledó JL, Rossi I et al. Continuous prazosin administration in cirrhotic patients: effects on portal hemodynamics and on liver and renal function. Gastroenterology. 1995;109:1257–65.
Bosch J. Decreasing hepatic vascular tone by liver-specific NO donors: wishful thinking or a promising reality? J Hepatol. 2003;39:1072–5.
Lee S, Hadengue A, Moreau R, Sayegh R, Hillon P, Lebrec D. Postprandial hemodynamic responses in patients with cirrhosis. Hepatology. 1988;8:647–51.
McCormick PA, Dick R, Graffeo M et al. The effect of non-protein liquid meals on the hepatic venous pressure gradient in patients with cirrhosis. J Hepatol. 1990;11:221–5.
Polio J, Groszmann RJ. Hemodynamic factors involved in the development and rupture of esophageal varices: a pathophysiologic approach to treatment. Semin Liver Dis. 1986; 6:318–31.
McCormick PA, Jenkins SA, McIntyre N, Burroughs AK. Why portal hypertensive varices bleed and bleed: a hypothesis. Gut. 1995;36:100–3.
García-Pagan JC, Santos C, Barberá JA et al. Physical exercise increases portal pressure in patients with cirrhosis and portal hypertension. Gastroenterology. 1996;111:1300–6.
Luca A, Cirera I, Garcia-Pagán JC et al. Hemodynamic effects of acute changes in intraabdominal pressure in patients with cirrhosis. Gastroenterology. 1993;104:222–7.
Bellis L, Berzigotti A, Abraldes JG et al. Low doses of isosorbide mononitrate attenuate the postprandial increase in portal pressure in patients with cirrhosis. Hepatology. 2003; 37:378–84.
Villanueva C, Ortiz J, Miñana J et al. Somatostatin treatment and risk stratification by continuous portal pressure monitoring during acute variceal bleeding. Gastroenterology. 2001;121:110–17.
Zafra C, Abraldes JG, Cortez C et al. Simvastatin ameliorates the increased hepatic vascular tone in patients with cirrhosis. J Hepatol. 2003;38(Suppl. 12):12.
Aracil C, López-Balaguer JM, Monfort D et al. Hemodynamic response to beta-blockers and prediction of clinical efficacy in the primary prophylaxis of variceal bleeding in patients with cirrhosis. Hepatology. 2003;38:296A (abstract).
Korula J, Ralls P. The effects of chronic endoscopic variceal sclerotherapy on portal pressure in cirrhotics. Gastroenterology. 1991;101:800–5.
Lo GH, Liang HL, Lai KH et al. The impact of endoscopic variceal ligation on the pressure of the portal venous system. J Hepatol. 1996;24:74–8.
De Franchis R, Primignani M. Endoscopic treatments for portal hypertension. Semin Liver Dis. 1999;19:439–55.
Laine L, Cook D. Endoscopic ligation compared with sclerotherapy for treatment of esophageal variceal bleeding. A meta-analysis. Ann Intern Med. 1995;123:280–7.
Burroughs AK, Patch D. Transjugular intrahepatic portosystemic shunt. Semin Liver Dis. 1999;19:457–73.
Escorsell A, Bañares R, García-Pagan JC et al. TIPS versus drug therapy in preventing variceal rebleeding in advanced cirrhosis: a randomized controlled trial. Hepatology. 2002;35:385–92.
Papatheodoridis GV, Goulis J, Leandro G, Patch D, Burroughs AK. Transjugular intrahepatic portosystemic shunt compared with endoscopic treatment for prevention of variceal rebleeding: a meta-analysis. Hepatology. 1999;30:612–22.
Adam R, Cailliez V, Majno P et al. Normalised intrinsic mortality risk in liver transplantation: European Liver Transplant Registry Group. Lancet. 2000;356:621–7.
Ready JB, Robertson AD, Goff JS, Rector WG. Assessment of the risk of bleeding from esophageal varices by continuous monitoring of portal pressure. Gastroenterology. 1991;100:1403–10.
Moitinho E, Escorsell A, Bandi JC et al. Prognostic value of early measurements of portal pressure in acute variceal bleeding. Gastroenterology. 1999;117:626–31.
Monescillo A, Martinez-Lagares F, Sierra A et al. Treatment of acute variceal bleeding by the hepatic venous pressure gradient: preliminary results of a randomized trial. Hepatology. 1999;30:220A (abstract).
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Villanueva, C., Aracil, C., Balanzó, J. (2004). What to do with non-responders. In: Groszmann, R.J., Bosch, J. (eds) Portal Hypertension in the 21st Century. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1042-9_34
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