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Hundred Years of Genetics: Revisiting some of the Landmarks

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Abstract

The human genome sequence report published in the year 2000 followed the rediscovery of Mendel’s laws of biological inheritance a hundred years earlier. The intervening period has been marked by major discoveries which have become landmarks in the history of genetics. The present paper recounts some of these landmark discoveries. The treatment is not exhaustive; rather an attempt has been made to show how one important finding followed another in rapid succession, as important questions were asked at each stage. This only indicates the intense interest of a large number of scientists from different disciplines as the young science started to unfold its potential as an integrating force in biology.

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References

  • Avery O. T., MacLeod C. M. and McCarty M. 1944. Studies on the chemical nature of the substance inducing transformation of pneumococcal types: Induction of transformation by a deoxyribonucleic acid fraction isolated from pneumococcus type III. J. Exp. Med., 79: 137.

    Article  PubMed  Google Scholar 

  • Bateson W. 1909. Mendel’s Principles of Heredity. Cambridge University Press, Cambridge, U. K.

    Book  Google Scholar 

  • Beadle G. W. and Tatum E. L. 1941. Genetic control of biochemical reaction in Neurospora, Proc. Natl. Acad Sci., 27: 499.

    Article  CAS  Google Scholar 

  • Benzer S. 1955. Fine structure of a genetic region in bacteriophage. Proc. Natl. Acad. Sci. 41: 344.

    Article  PubMed  CAS  Google Scholar 

  • Botstein D., White R. L., Sholnick M. and Davies R. W. 1980. Construction of a genetic linkage map in man using restriction fragment polymorphism. Amer. J. Human Genetics, 32: 314.

    CAS  Google Scholar 

  • Boveri T. 1902. Uber mehrpolige Mitosen als Mittel zur Analyse der Zelkerns. Verh. phys. Med. Gesellsch. Wurzburg. 35: 67.

    Google Scholar 

  • Brenner S., Stretton A. O. W, and Kaplan S. 1965. Genetic code: The “non-sense” triplets for chain termination and their suppression. Nature, 206: 994.

    Article  PubMed  CAS  Google Scholar 

  • Bridges C. B. 1916. Nondisjuction as a proof of the chromosome theory of heredity. Genetics, 1: 107.

    PubMed  CAS  Google Scholar 

  • Britten R. J. and Kohne D. E. 1968. Repeated sequences in DNA. Science, 161: 359.

    Article  Google Scholar 

  • Chargaff E. 1950. Chemical specificity of the nucleic acids and mechanism of their enzymatic degradation. Experientia, 6: 201.

    Article  PubMed  Google Scholar 

  • Correns C. 1900. G. Mendel Regel uber das Verhalten der Nachkommenschft der Rassenbastarde. Ber. deutsch. botan. Gesellsch, 18: 158. English translation available in The Birth of Genetics, published as a supplement to 1950 volume of Genetics, 33-41.

    Google Scholar 

  • Creighton M. R. and McClintock B. 1931. A correlation of cytological and genetical crossing over in Zea mays. Proc. Natl. Acad. Sci., 17: 485.

    Article  Google Scholar 

  • Crick F. H. C., Barnett L, Brenner S. and Watts-Tobin R. J. 1961. General nature of the genetic code for proteins. Nature, 192: 1227.

    Article  PubMed  CAS  Google Scholar 

  • Darlington C. D. 1965. Recent Advances in Cytology. Churchill, London.

    Google Scholar 

  • Darwin C. 1859. The Origin of Species, John Muray, London, U. K.

    Google Scholar 

  • De Vries H. 1900. Sur la loi de disjoinetion des hybrids, C. R. Acad. Sci. (Paris), 130: 845. (See English translation in The Birth of Genetics, Suppl. Genetics, 1950, volume 30-32.

    Google Scholar 

  • Dobzhansky Th. 1970. Genetics of the Evolutionary Process. Columbia University Press, New York.

    Google Scholar 

  • Doolittle W. F. and Sapienza. 1980. Selfish genes, the phenotype paradigm, and genome evolution. Nature, 284: 601–603.

    Article  PubMed  CAS  Google Scholar 

  • East E. M. 1916. Studies on size inheritance in Nicotiana. Genetica, 1: 164.

    CAS  Google Scholar 

  • Fisher R. A. 1930. The Genetical Theory of Natural Selection. Clarendon Press, Oxford, U. K.

    Google Scholar 

  • Freeze E. 1959. The difference between spontaneous and base-analogue induced mutations of phage T4. Proc. Natl. Acad. Sci., 45: 622.

    Article  Google Scholar 

  • Freese E. 1963. Molecular Mechanisms of Mutations. In: Molecular Genetics, Part 1, (ed. ) J. H. Taylor, Academic Press, New York, pp. 207.

    Google Scholar 

  • Gilbert W. and Muller-Hill B. 1965. Isolation of the lac repressor. Proc. Natl. Acad. Sci., 58: 2415.

    Article  Google Scholar 

  • Garrod A. E. 1909. Inborn Errors of Metabolism. Oxford Univ. Press, Oxford, U. K.

    Google Scholar 

  • Griffith F. 1928. The significance of pneumococcal types. J. Hygiene, 27: 113.

    Article  CAS  Google Scholar 

  • Haidane J. B. S. 1932. The Causes of Evolution, Longman, London.

    Google Scholar 

  • Hershey A. D. and Chase M. 1952. Independent functions of viral protein and nucleic acid in growth of bacteriophage. J. Gen. Physiol., 36: 39.

    Article  PubMed  CAS  Google Scholar 

  • International Human Genome Sequencing Consortium. 2001. Initial sequencing and analysis of the human genome. Nature, 409: 860.

    Article  Google Scholar 

  • Jacob F. and Monod J. 1961. Genetic regulatory mechanisms in the synthesis of proteins. J. Mol. Biol., 3: 318.

    Article  PubMed  CAS  Google Scholar 

  • Jain H. K. 1980. Incidental DNA. Nature, 288: 647.

    Article  PubMed  CAS  Google Scholar 

  • Johannsen W. 1909. Elemente der Exakten Erblichkeitslehre, Fisher, Jena 516 pp. Classic Papers in Genetics, (ed. ) Peters J. A., Prentice Hall, 1959.

    Google Scholar 

  • Khorana H. G., Bochi H., Ghosh H., Gupta H., Jacob F., Kossel T. M., Morgan R., Narang R., Ohtsuka S. A. and Wells R. D. 1967. Polynucleotide synthesis and the genetic code. Cold. Symp. Harb. Symp. Quant. Biol., 31: 39.

    Article  Google Scholar 

  • Lederberg J. and Tatum E. L. 1946. Gene recombination in E. coli, Nature, 158: 558.

    CAS  Google Scholar 

  • Lindergren C. C. 1993. The genetics of Neurospora III. Pure bred stocks and crossing over in N. crassa, Bull. Torrey Bot. Club, 60: 133.

    Article  Google Scholar 

  • Luria S. E. and Delbruck M. 1943. Mutation of bacteria from virus sensitivity to virus resistance. Genetics, 28. 491.

    PubMed  CAS  Google Scholar 

  • Mather K. 1943. Polygenic inheritance and natural selection. Biol. Rev., 18: 32.

    Article  Google Scholar 

  • McClintock B. 1951. Chromosome organization and gene expression. Cold Spring Harb. Symp., 16: 13–47.

    Article  CAS  Google Scholar 

  • McClung C. E. 1901. Notes on the accessory chromosome. Anat. Anz., 20: 220.

    Google Scholar 

  • Mendel G. J. 1866. Versuche uber Pflanzenhybriden. Verh. Naturforsch. Ver. Brunn., 4: 3–47. Following English translation are available: J. Roy. Hort. Soc, 26; Mendel’s Principles of Heredity, Gabriel and Fogel, 1955; Classic Papers in Genetics, (ed. ) Peters J. A., Prentice Hall, 1959.

    Google Scholar 

  • Meselson M. and Stahl F. W. 1958. The replication of DNA in E. coli. Proc. Natl. Acad. Sci., 44: 671.

    Article  CAS  Google Scholar 

  • Morgan T. H. 1910. Sex limited inheritance in Drosophila. Science, 32: 120.

    CAS  Google Scholar 

  • Morgan T. H. and Bridges C. B. 1916. Sex-linked inheritance in Drosophila. Carnegie Inst. Wash. Publ. No. 237: 1.

    Google Scholar 

  • Muller H. J. 1927. Artificial transmutation of the gene. Science, 66: 84.

    Article  PubMed  CAS  Google Scholar 

  • Muller H. J. 1962. Studies in Genetics. The Selected Papers of H. J. Muller. Indiana University Press, with a foreword by Joshua Lederberg and a tribute to Muller as a Teacher by G. Pontecurvo.

    Google Scholar 

  • Nirenberg M. W. and Matthei J. H. 1961. The dependence of cell-free protein synthesis in E. coli upon naturally occurring or synthetic polyribonucleotides. Proc. Natl. Acad. Sci., 47: 1588.

    Article  PubMed  CAS  Google Scholar 

  • Nirenberg M. W. and Leder P. 1964. RNA codewords and protein synthesis: The effect of trinucleotides upon the binding of sRNA to ribosomes. Science, 145: 1399.

    Article  PubMed  CAS  Google Scholar 

  • Orgel L. E. and Crick F. H. C. 1980. Selfish DNA: The ultimate parasite. Nature, 284: 604–607.

    Article  PubMed  CAS  Google Scholar 

  • Rich Alexander. 1995. The nucleic acids. A backward glance. In: DNA: The Double Helix. (ed. ) Donald A. Chambers, The New York Academy of Sciences, pp. 97–142.

    Google Scholar 

  • Sarabhai A., Stretton A. D. W., Brenner S. and Bolle A. 1964. Colinearity of the gene with polypeptide chain. Nature, 201: 13.

    Article  PubMed  CAS  Google Scholar 

  • Smith H. O. 1979. Nucleotide sequence specificity of restriction endonucleases. Science, 205: 455–462.

    Article  PubMed  CAS  Google Scholar 

  • Sturtevant A. H. 1913. The linear arrangement of sex-linked factors in Drosophila as shown by their mode of association. Exp. Zool, 14: 43.

    Article  Google Scholar 

  • Sutton W. S. 1902. The Chromosomes in heredity. Biol. Bull., 4: 231.

    Article  Google Scholar 

  • Taylor J. H., Woods P. S. and Hughes W. I. 1957. The organisation and duplication of chromosomes as revealed by autoradiographic studies using tritium labelled thymidine. Proc. Natl. Acad. Sci, 45: 122.

    Article  Google Scholar 

  • Tschermak E. 1900. Ueber kunstliche Kreuzung bei Pisum sativum. Zeits. Landw. Verschsw. Oesterr., 3. Heft 5. English translation in The Birth of Genetics, supplement to 1950. (volume 35) of Genetics.

    Google Scholar 

  • Venter J. C. et al. 2001. The sequence of the human genome. Science, 291: 1304.

    Article  PubMed  CAS  Google Scholar 

  • Watson J. D. and Crick F. H. C. 1953a. A structure for deoxyribose nucleic acid. Nature, 171: 131.

    Google Scholar 

  • Watson J. D. and Crick F. H. C. 1953b. Genetical implications of the structure of deoxyribonucleic acid. Nature, 171: 964.

    Article  PubMed  CAS  Google Scholar 

  • Wilkins M. H. F., Stokes A. R. and Wildon H. R. 1953. Molecular structure of deoxypentose nucleic acids. Nature, 171: 738.

    Article  PubMed  CAS  Google Scholar 

  • Wilson E. B. 1905. The chromosomes in relation to the determination of sex in insects. Science, 22: 500–502.

    Article  PubMed  CAS  Google Scholar 

  • Witkin E. M. 1969. The role of DNA repair and recombination in mutagenesis. Proc. XII Intern. Congr. Genetics, 3: 225.

    Article  Google Scholar 

  • Wright S. 1951. Genetic structure of populations. Ann. Eugenics, 15: 323–354.

    Google Scholar 

  • Wright S. 1978. Evolution and the Genetics of Populations, Vol. 4., Variability within and among natural population. The University of Chicago Press, Chicago.

    Google Scholar 

  • Yanofsky C. 1960. The tryptophan synthetase systems. Bact. Rev., 24: 221.

    PubMed  CAS  Google Scholar 

  • Yanofsky C., Horn V. and Thorpe D. 1964. Protein structure relationships revealed by mutational analysis. Science, 146: 1593.

    Article  PubMed  CAS  Google Scholar 

  • Yanofsky C., Cox E. C. and Horn V. 1966. The unusual specificity of an E. coli mutator gene. Proc. Nat. Acad. Sci., 55: 274–281.

    Article  PubMed  CAS  Google Scholar 

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H K Jain M C Kharkwal

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Jain, H.K. (2004). Hundred Years of Genetics: Revisiting some of the Landmarks. In: Jain, H.K., Kharkwal, M.C. (eds) Plant Breeding. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1040-5_1

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  • DOI: https://doi.org/10.1007/978-94-007-1040-5_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3773-0

  • Online ISBN: 978-94-007-1040-5

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