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Principles of drug administration in children receiving renal replacement therapy

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Book cover Pediatric Dialysis

Abstract

The prescription of a safe and effective dose of a medication for a child receiving dialysis is an arduous task as both renal failure and dialysis can modify the absorption, distribution, metabolism, elimination and action of a drug. A safe and effective dosing regimen is one that delivers the appropriate drug in the optimal manner, producing the desired pharmacological response while minimizing the undesirable effects. Achieving the goal of successful drug therapy requires a clear understanding of the therapeutic goal coupled with an appreciation of the factors governing drug disposition and action. Failure to clearly identify the therapeutic goal or to account for the changes in drug disposition associated with renal failure and the performance of dialysis can culminate in drug toxicity or inadequate treatment.

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Authors
  1. D. L. Blowey
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Editors and Affiliations

  1. Children’s Mercy Hospital, University of Missouri, Kansas City School of Medicine, Kansas City, MO, USA

    Bradley A. Warady

  2. University Children’s Hospital, Heidelberg, Germany

    Franz S. Schaefer

  3. Health Science Center, State University of New York at Stony Brook, Stony Brook, NY, USA

    Richard N. Fine

  4. Lucille Packard Children’s Hospital at Stanford, Stanford University, School of Medicine, Stanford, CA, USA

    Steven R. Alexander

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Blowey, D.L. (2004). Principles of drug administration in children receiving renal replacement therapy. In: Warady, B.A., Schaefer, F.S., Fine, R.N., Alexander, S.R. (eds) Pediatric Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1031-3_33

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  • DOI: https://doi.org/10.1007/978-94-007-1031-3_33

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