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Blood pressure management in the dialysis patient

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Pediatric Dialysis

Abstract

Cardiovascular disease is highly prevalent and the leading cause of mortality in adults receiving chronic dialysis1. Recent reports have shown that cardiovascular deaths are more than 1000-fold higher in children with end-stage renal disease (ESRD) than in the general age-matched population and account for approximately one-quarter of all pediatric and young adult deaths in this population2. The cause of this extremely high cardiovascular death rate likely includes some combination of the risk factors of hypertension, arteriosclerosis, chronic volume overload leading to dilated cardiomyopathy, left ventricular hypertrophy (LVH), left ventricular conduction abnormalities, coronary disease, small vessel disease, and uremia. Although the cardiovascular disease is multifactorial, hypertension is one of the major risk factors for cardiovascular disease in all patient populations and thus should be considered to have important pathogenic significance for the specific population of children with ESRD. The goal of this chapter will be to focus on the specific issue of hypertension in the pediatric ESRD population by reviewing current concepts in the definition, pathogenesis, evaluation, and management of hypertension in the pediatric dialysis patient.

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References

  1. Hörl MP, Hörl WH. Hemodialysis-associated hypertension: pathophysiology and therapy. Am J Kidney Dis. 2002;39:227–44.

    Article  PubMed  Google Scholar 

  2. Parekh RS, Carroll CE, Wolfe RA et al. Cardiovascular mortality in children and young adults with end-stage kidney disease. J Pediatr. 2002;141:191–7.

    Article  PubMed  CAS  Google Scholar 

  3. Blumenthal S, Epps RP, Heavenrich R et al. Report of the task force on blood pressure control in children. Pediatrics. 1977;59:797–820.

    Google Scholar 

  4. Task force on blood pressure control in children: report of the second Task Force on blood pressure control in children-1987. Pediatrics. 1987;79:1–25.

    Google Scholar 

  5. Update on the 1987 Task Force Report on high blood pressure in children and adolescents: a working group report from the National High Blood Pressure Education Program. National High Blood Pressure Education Program Working Group on hypertension control in children and adolescents. Pediatrics. 1996;98:649–58.

    Google Scholar 

  6. Sorof JM, Daniels SR. Obesity hypertension in children. A problem of epidemic proportions. Hypertension. 2002; 111:441–7.

    Article  Google Scholar 

  7. Lingens N, Soergel M, Loirat C et al. Ambulatory blood pressure monitoring in paediatric patients treated by regular haemodialysis and peritoneal dialysis. Pediatr Nephrol. 1995; 9:167–72.

    Article  PubMed  CAS  Google Scholar 

  8. Sorof JM, Brewer ED, Portman RJ. Ambulatory blood pressure monitoring and interdialytic weight gain in children receiving chronic hemodialysis. Am J Kidney Dis. 1999;33:667–74.

    Article  PubMed  CAS  Google Scholar 

  9. Verdecchia P, Porcellati C, Schillaci G et al. Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension. Hypertension. 1994;24:793–801.

    Article  PubMed  CAS  Google Scholar 

  10. Sorof JM, Portman RJ. Ambulatory blood pressure monitoring in the pediatric patient. J Pediatr. 2000;136:578–86.

    Article  PubMed  CAS  Google Scholar 

  11. Gomez-Marin O, Prineas RJ, Rastam L. Cuff bladder width and blood pressure measurement in children and adolescents. J Hypertens. 1992; 10:1235–41.

    Article  PubMed  CAS  Google Scholar 

  12. Frauman AC, Lansing LM, Fennell RS. Indirect blood pressure measurement in children undergoing hemodialysis: a comparison of brachial and dorsalis pedis auscultatory sites. AANNT J. 1984;11:19–21.

    PubMed  CAS  Google Scholar 

  13. Port FK, Hulbert-Shearon TE, Wolfe RA et al. Predialysis blood pressure and mortality risk in a national sample of maintenance hemodialysis patients. Am J Kidney Dis. 1999;33:507–17.

    Article  PubMed  CAS  Google Scholar 

  14. Kooman JP, Gladziwa U, Bocker G et al. Blood pressure during the interdialytic period in haemodialysis patients: estimation of representative blood pressure values. Nephrol Dial Transplant. 1992;7:917–23.

    PubMed  CAS  Google Scholar 

  15. Conion PJ, Walshe JJ, Heinle SK et al. Predialysis systolic blood pressure correlates strongly with mean 24-hour systolic blood pressure and left ventricular mass in stable hemodialysis patients. J Am Soc Nephrol. 1996;7:2658–63.

    PubMed  CAS  Google Scholar 

  16. Rahman M, Griffin V, Kumar A et al. A comparison of standardized versus “usual” blood pressure measurements in hemodialysis patients. Am J Kidney Dis. 2002;39:1226–30.

    Article  PubMed  Google Scholar 

  17. Cheigh JS, Milite C, Sullivan JF et al. Hypertension is not adequately controlled in hemodialysis patients. Am J Kidney Dis. 1992;19:453–9.

    PubMed  CAS  Google Scholar 

  18. Klassen PS, Lowrie EG, Reddan DN et al. Association between pulse pressure and mortality in patients undergoing maintenance hemodialysis. JAMA. 2002;287:1548–55.

    Article  PubMed  Google Scholar 

  19. Lerner GR, Warady BA, Sullivan EK et al. Chronic dialysis in children and adolescents. The 1996 annual report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Nephrol. 1999;13:404–17.

    Article  PubMed  CAS  Google Scholar 

  20. Zurowska A, Balasz I, Zagozdzon I et al. Hypertension in children with chronic renal failure. Pol Merkuriusz Lek. 2000;8:259–60.

    CAS  Google Scholar 

  21. Groothoff JW, Gruppen MP, Offringa M et al. Mortality and causes of death of end-stage renal disease in children: a Dutch cohort study. Kidney Int. 2002;61:621–9.

    Article  PubMed  Google Scholar 

  22. Chavers BM, Li S, Collins AJ et al. Cardiovascular disease in pediatric chronic dialysis patients. Kidney Int. 2002;62:648–53.

    Article  PubMed  Google Scholar 

  23. Leypoldt JK, Cheung AK, Delmez JA et al. Relationship between volume status and blood pressure during chronic hemodialysis. Kidney Int. 2002;61:266–75.

    Article  PubMed  Google Scholar 

  24. Peco-Antic A, Pejcic I, Stojanov V et al. Ambulatory blood pressure monitoring in chronic haemodialysis children with end-stage renal failure. Nephron. 1996;72:739–40.

    Article  PubMed  CAS  Google Scholar 

  25. Goonasekera CD, Dillon MJ. Vascular endothelium and nitric oxide in childhood hypertension. Pediatr Nephrol. 1998;12:676–89.

    Article  PubMed  CAS  Google Scholar 

  26. Konings CJ, Dammers R, Rensma PL et al. Arterial wall properties in patients with renal failure. Am J Kidney Dis. 2002;39:1206–12.

    Article  PubMed  Google Scholar 

  27. Nayir A, Bilge I, Kilicaslan I et al. Arterial changes in paediatric haemodialysis patients undergoing renal transplantation. Nephrol Dial Transplant. 2001;16:2041–7.

    Article  PubMed  CAS  Google Scholar 

  28. Lebel M, Kingma I, Grose JH et al. Hemodynamic and hormonal changes during erythropoietin therapy in hemodialysis patients. J Am Soc Nephrol. 1998;9:97–104.

    PubMed  CAS  Google Scholar 

  29. Ni Z, Wang XQ, Vaziri ND. Nitric oxide metabolism in erythropoietin-induced hypertension: effect of calcium channel blockade. Hypertension. 1998;32:724–9.

    Article  PubMed  CAS  Google Scholar 

  30. Kaupke CJ, Kim S, Vaziri ND. Effect of erythrocyte mass on arterial blood pressure in dialysis patients receiving maintenance erythropoietin therapy. J Am Soc Nephrol. 1994;4:1874–8.

    PubMed  CAS  Google Scholar 

  31. Vaziri ND, Zhou XJ, Naqvi F et al. Role of nitric oxide resistance in erythropoietin-induced hypertension in rats with chronic renal failure. Am J Physiol. 1996;271:E113–22.

    PubMed  CAS  Google Scholar 

  32. Vaziri ND, Ni Z, Wang XQ et al. Downregulation of nitric oxide synthase in chronic renal insufficiency: role of excess PTH. Am J Physiol. 1998;274:F642–9.

    PubMed  CAS  Google Scholar 

  33. Brem AS, Lambert C, Hill C et al. Clinical morbidity in pediatric dialysis patients: data from the Network 1 Clinical Indicators Project. Pediatr Nephrol. 2001;16:854–7.

    Article  PubMed  CAS  Google Scholar 

  34. Silberberg JS, Barre PE, Prichard SS et al. Impact of left ventricular hypertrophy on survival in end-stage renal disease. Kidney Int. 1989;36:286–90.

    Article  PubMed  CAS  Google Scholar 

  35. Causes of death. USRDS. United States Renal Data System. Am J Kidney Dis. 1997; 30:S107–17.

    Google Scholar 

  36. Mitsnefes MM, Daniels SR, Schwartz SM et al. Severe left ventricular hypertrophy in pediatric dialysis: prevalence and predictors. Pediatr Nephrol. 2000;14:898–902.

    Article  PubMed  CAS  Google Scholar 

  37. Mitsnefes MM, Schwartz SM, Daniels SR et al. Changes in left ventricular mass index in children and adolescents after renal transplantation. Pediatr Transplant. 2001;5:279–84.

    Article  PubMed  CAS  Google Scholar 

  38. Goodman WG, Goldin J, Kuizon BD et al. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med. 2000;342:1478–83.

    Article  PubMed  CAS  Google Scholar 

  39. de Simone G, Devereux RB, Daniels SR et al. Effect of growth on variability of left ventricular mass: assessment of allometric signals in adults and children and their capacity to predict cardiovascular risk. J Am Coll Cardiol. 1995;25:1056–62.

    Article  PubMed  Google Scholar 

  40. Roman MJ, Alderman MH, Pickering TG et al. Differential effects of angiotensin converting enzyme inhibition and diuretic therapy on reductions in ambulatory blood pressure, left ventricular mass, and vascular hypertrophy. Am J Hypertens. 1998;11:387–96.

    Article  PubMed  CAS  Google Scholar 

  41. Laurent G. How to keep the dialysis patients normotensive? What is the secret of Tassin? Nephrol Dial Transplant. 1997;12:1104.

    Article  PubMed  CAS  Google Scholar 

  42. Katzarski KS, Charra B, Luik AJ et al. Fluid state and blood pressure control in patients treated with long and short haemodialysis. Nephrol Dial Transplant. 1999;14:369–75.

    Article  PubMed  CAS  Google Scholar 

  43. Krautzig S, Janssen U, Koch KM et al. Dietary salt restriction and reduction of dialysate sodium to control hypertension in maintenance haemodialysis patients. Nephrol Dial Transplant. 1998;13:552–3.

    Article  PubMed  CAS  Google Scholar 

  44. Ökahya M, Toz H, Unsal A et al. Treatment of hypertension in dialysis patients by ultrafiltration: role of cardiac dilatation and time factor. Am J Kidney Dis. 1999;34:218–21.

    Article  Google Scholar 

  45. Fishbane S, Natke E, Maesaka JK. Role of volume overload in dialysis-refractory hypertension. Am J Kidney Dis. 1996;28:257–61.

    Article  PubMed  CAS  Google Scholar 

  46. Hagberg JM, Goldberg AP, Ehsani AA et al. Exercise training improves hypertension in hemodialysis patients. Am J Nephrol. 1983;3:209–12.

    Article  PubMed  CAS  Google Scholar 

  47. Mittal SK, Kowalski E, Trenkle J et al. Prevalence of hypertension in a hemodialysis population. Clin Nephrol. 1999;51:77–82.

    PubMed  CAS  Google Scholar 

  48. Soergel M, Schaefer F. Effect of hypertension on the progression of chronic renal failure in children. Am J Hypertens. 2002;15:S53–56.

    Article  Google Scholar 

  49. Grim CE, Luft FC, Miller JZ et al. Racial differences in blood pressure in Evans county, Georgia: relationship to sodium and potassium intake and plasma renin activity. J Chron Dis. 1980;33:87–94.

    Article  PubMed  CAS  Google Scholar 

  50. Nuutinen M, Lautala P, Remes M et al. Nephrectomy in severe hypertension. Clin Nephrol. 2000;54:342–6.

    PubMed  CAS  Google Scholar 

  51. Ponticelli C, Montagnino G, Aroldi A et al. Hypertension after renal transplantation. Am J Kidney Dis. 1993;21:73–8.

    PubMed  CAS  Google Scholar 

  52. Opelz G, Wujciak T, Ritz E. Association of chronic kidney graft failure with recipient blood pressure. Collaborative Transplant Study. Kidney Int. 1998;53:217–22.

    Article  PubMed  CAS  Google Scholar 

  53. Morgan H, Khan I, Hashmi A et al. Ambulatory blood pressure monitoring after renal transplantation in children. Pediatr Nephrol. 2001;16:843–7.

    Article  PubMed  CAS  Google Scholar 

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© 2004 Springer Science+Business Media Dordrecht

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Samuels, J.A., Sorof, J.M. (2004). Blood pressure management in the dialysis patient. In: Warady, B.A., Schaefer, F.S., Fine, R.N., Alexander, S.R. (eds) Pediatric Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1031-3_20

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  • DOI: https://doi.org/10.1007/978-94-007-1031-3_20

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3770-9

  • Online ISBN: 978-94-007-1031-3

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