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Vanadium pp 163-185 | Cite as

Vanadium in Cancer Prevention

  • Subhadeep Das
  • Mary Chatterjee
  • Muthumani Janarthan
  • Hari Ramachandran
  • Malay Chatterjee
Chapter

Abstract

The pharmacological role of vanadium in health and disease remains one of the fascinating stories in biology. Recent studies have established vanadium as a novel regulator in assessing physiological and biochemical states of the animals. Vanadium exhibits biphasic effect, essentiality at low concentrations (0.05 μM) and toxicity at high doses (>10 μM). Vanadium inhibits growth of transformed cancer cells in culture. Various laboratories have confirmed the antitumorigenic potential of vanadium in liver, breast and colon cancer in vivo and various human cancer epithelial cell lines in vitro. Antiproliferative and induction of apoptosis may be the major mechanism of vanadium mediated inhibitions of cancer. Vanadium can play a central role in modulating phosphorylation states of various proteins in the cell and can affect many cellular processes regulated by cyclic AMP. In human vanadium is of interest pharmacologically but confirmation to its essentiality will require more significant information from experimental, clinical and epidemiological studies.

Keywords

Vanadium Cancer DNA damage Antiproliferative Key regulator 

Notes

Acknowledgement

We thank Subrata Pramanik (M. Pharm.), Rohullah Roien (M. Pharm.) and Dr. Kaushik Roy for their continuous help and support for the preparation of the manuscript.

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© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Subhadeep Das
    • 1
  • Mary Chatterjee
    • 1
  • Muthumani Janarthan
    • 1
  • Hari Ramachandran
    • 2
  • Malay Chatterjee
    • 1
  1. 1.Chemical Carcinogenesis and Chemoprevention Laboratory, Department of Pharmaceutical TechnologyJadavpur UniversityKolkataIndia
  2. 2.Department of SurgeryColumbia UniversityNew YorkUSA

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