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Chromosome 9

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Human Chromosome Variation: Heteromorphism and Polymorphism

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Abstract

The lightly-stained secondary constriction of chromosome 9 by plain Giemsa distinguishes it from other C-group chromosomes (Patau et al., Lancet i:790–793, 1960; Ferguson-Smith et al., Cytogenetics 1:325–343, 1962; Palmer and Funderburk, Cytogenetics 4:261–276, 1965). By G-banding, the secondary constriction itself stains lightly, but bands on either side of the centromere typically stain as intensely as the pericentromeric regions of other chromosomes (Fig. 14.1a–i). By C-banding or DA/DAPI staining, the entire region, including the pericentromeric bands usually consists of a uniform block of dark or brightly staining heterochromatin (Fig. 14.1m, n). Sometimes, however, blocks of heterochromatin will appear to be separated by a G-positive, C-negative band (Fig. 14.1j, k). More rarely, such C-negative bands can be quite striking and have been the object of considerable study (see Euchromatic Variants). The 9qh region is also strikingly stained by Giemsa-11 (Fig. 2.4) (Bobrow et al., Nature New Biol 238:122–124, 1972; Wyandt et al., Exp Cell Res 102:85–94, 1976).

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Authors and Affiliations

  1. Boston University School of Medicine Center for Human Genetics, Boston, Massachusetts, USA

    Dr. Herman E. Wyandt

  2. Acupath Laboratories, Inc., 28 South Terminal Drive, 11803, Plainview, New York, USA

    Dr. Herman E. Wyandt

  3. Department of Pediatrics, Texas Tech University Health Science Center, 4th Street 3601, 79416, Lubbock, Texas, USA

    Dr. Vijay S. Tonk

Authors
  1. Dr. Herman E. Wyandt
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  2. Dr. Vijay S. Tonk
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Correspondence to Herman E. Wyandt or Vijay S. Tonk .

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Wyandt, H.E., Tonk, V.S. (2011). Chromosome 9. In: Human Chromosome Variation: Heteromorphism and Polymorphism. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0896-9_14

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